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LAWSUITS NEWS & LEGAL INFORMATION

Maxipime

The FDA issued an early communication about the ongoing review of new safety data and the request for additional data to further evaluate the risk of death in patients treated with Cefepime. An article in the May 2007 issue of The Lancet Infectious Diseases (Efficacy and safety of Cefepime: a systematic review and meta analysis) raised the question about increased mortality with the use of Cefepime, a broad spectrum B-lactam antibiotic currently approved for the treatment of a variety of infections due to susceptible strains of microorganisms.

The article describes a higher all-cause mortality in patients treated with Cefepime compared to other B-lactam antibiotics. Until FDA's evaluation is completed, healthcare professionals who are considering the use of cefepime should be aware of the risks and benefits described in the product's prescribing information and the new information from this meta-analysis.

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Published on Nov-15-07


READER COMMENTS

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My mom Alicia Rodriguez was a 76 year old woman with a history of strokes, high blood pressure, AFIB, diabetes, and chronic medical renal disease. She was transported to The Hospital of Providence East on 09/29/2022 from Pebble Creek Nursing home for a possible UTI. She had a foley catheter since 09/06/2022 and was not properly taken care of by the nursing staff. When she was taken to the E.R. she was on an altered mind status. She was admitted and place on Ceftriaxone 1g and Levoflaxcin 500 mg. An NGT was placed due to her inability to eat, and a Nephrologist consulted her due to chronic renal issues. My mom’s antibiotic was changed to Cefepine on 10/4/2022 during night hours. I was unaware of the change in antibiotics until 10/5/2022. I received a phone call at 1238 from a nurse asking about my mom’s allergic reaction to Zosyn. I informed her she went into an aphylactic shock and had to intubated. The nurse told me the doctor wanted a baseline of my mom’s personality and the reaction to Zosyn. The nurse then said that her antibiotic was changed the night before. When I saw my mom on 10/5/2022 at 1015 am she was very agitated, she was in discomfort and was very itchy in her vaginal area. I asked one of the tech’s if they could give her a bed bath because her skin looked red and itchy. When I returned at 1330 hours to see my mom. My mom looked very disheveled, she looked catatonic, she had pulled NGT tube out and a watery diarrhea bowel movement. Despite a camera located in front of her bed, nurses did not see the state my mom was in. I had to alert them. Later my mom vomited a brownish-black bile. I noticed my mom’s stomach was inflamed. She continued to be very agitated. Her left leg was extremely cold. I talked to the doctor, and she mentioned her plan was to leave my mom on Cefepime for the next three days. I went home at 1630 hours and returned to the hospital at 1900 hours. My mom was under a code blue alert and CPR was done. My mom had no pulse. However, they found a pulse and took her to ICU from the Telemetry floor. The doctor ran to me and told me she didn’t know what happened. She didn’t see this outcome and had no answer as to why my mom went into cardiac arrest.

My mom died that night. A black-brownish liquid came out of her mouth before passing. I believe my mom had a toxic death due to Cefepine. How can her blook lab change dramatically hours after Cefepine was given to her. Why was Cefepine given to her if she had renal failure? Why didn’t medical personnel inform me that Cefepine is dangerous to renal failure patients.

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