Prolia LInked to Serious Adverse Events in FDA Reporting System

I need help my teeth fall out and my skin is so dry I could not have dental work for 2 years after prolia nor any invasive procedures not even a flue shot my moth hurts all the time my back hurts all the time I spent all I had to try to stop my tooth loss no dentist would take my insurance I am in agony physically and mentally I live check to check with no extras

I had my first and last Prolia injection last month. I'm so angry at myself for not researching this drug! Now I'm terrified of the side effects! I already have increased body pain, shakiness, muscle spasms, swelling in my knees and loss of appetite. I'm so afraid of the dental/jaw problems. I will see an Endocrinologist this Friday to talk about a relay drug so that I don't suffer the rebound effect of spontaneous spinal fractures. All I can do now is pray!! There has to be a way to flush this poison out of my system! Shame on the FDA for approving this!

I received 2 injections of Prolia and as a result have lost my teeth. My jawbone is deteriorating, and my teeth had become loose, causing me to have all my teeth removed. I have spent over $10,000 trying to save them but couldn't. I have terrible pain in my jaw when I try to eat which I never had before. All of the dentists that I have gone to, trying to save my teeth, told me there was nothing they could do because my jawbone was too thin, and I can't have implants.
I am in such a depression because I always had good teeth, now I have none.

I'm 87 years old, sister 85 years old ,and sister 90 years old, we all have had 5 - 6 Prolia vaccinations, all have had side effects. My 85 year old sister has had mega side effects, such as, excruciating pain in her shoulders, bones, etc. The pain was so severe that she went to ER, was admitted and several tests ran, they discoverd her left heart ventrical was functioning at 17 percent, The temporary relief she can get is from strong pain meds, which cardiologist monitors. She was scheduled for a Prolia shot in Nov.2023 and declined to get it due to controversial news. It would have been her 6th shot. She has been experincing pain for several months.
My pain (87yr old) was in my right upper shoulder felt like it could be in the muscle, that's how I described it, a rash apeared the 3rd day, I went to Urgent care and told them I thought I had shingles,treated with antiviral meds, it went away. This occurred 2 more times. I have had the shingle shot. The pain was horrible!!
My 90 yr. old sisters pain in her shoulders was treated with over the counter pain. I question why an 85, 87, 90 years old people are told they should get this.

Prolia caused me to have my Jaw replaced with a bone and vain out of my leg. It was an 8 hour surgery and I was on a feeding tube and had a trach. worse than my cancer. Been over a year and my jaw still hurts.

after the 3rd shot of prolia extreme pains in legs and dependent edema-No cardiac issues-Quite frankly it has made me miserable. Never again.

Prolia has destroyed my teeth and other bones please help

Prolia has caused two lower right molars to be displaced; an oral surgeon had to extract them. After the molar extractions, he has had to repeatedly extract bone eruptions coming from under the gum that are as sharp as tiny knives. X-rays indicate that I will have to undergo multiple procedures in the near future to remove these bone shards, with no end in sight. He has contacted the prescribing MD, arranging for a pause re further injections of Prolia until he can get the dental situation under control. I now worry about spinal fractures when Prolia is paused. I also worry about the dental costs..

Prolia caused my teeth to rupture at the roots, my saliva ducts have stopped producing saliva and I have an ongoing painful tingling sensation in my jaw. I also have pain in my upper legs and hips and I am now bed bound at 53 years of age. I will never lead a normal life again.

Please contact me if there is a lawsuit that I can join. Prolia has ruined my life. Thank you and best wishes to all of the other victims of Prolia.

I received my first Prolia shot in 2017. I developed hip pain shoulder pain. Numbness in my feet. In 2020 I developed a painful itchy rash on lower legs after receiving another shot. It is now 2022 and my whole body is covered. Intense itch. Feels like I am hugging a pin cushion. I mentioned rash years ago to oncologist who prescribed the Prolia that it may be from shot and she said no. She told me to see Mayo Clinic Dermatologist. Well I did and guess what blood work showed severe high level of my immune system fighting off a reaction to something. It was 600 times over normal limit. She knew immediately after looking at my case history. I just had complete retinal detachment surgery too. My rash is painful that clothing pulls and cases bleeding. I have small purple blood specs under the skin. This is a dangerous drug and yet the prescribers don’t even mention the side effects especially when presented symptoms right in front of them. I am 66 years,old and this has ruined my quality of life. Drug needs to be removed.

Took one (and only) Prolia shot in June 2021. I have NEVER had any labs that weren't positively normal UNTIL I took the Prolia. BUN and BUN/Creatinine ratio were DOUBLED but gfr was ok in labs done in Oct. 2021. Went to my PCP who repeated the labs in Dec. 2021. BUN and BUN/Creatinine ratio are almost back in normal range BUT.... now gfr is a little low. Hair has fallen out or broke off in gobs. Itching is so irritating. Sinus issues and ear congestion and ringing in the right ear. I was so dizzy I was bumping into walls. It seems the risks involved in taking Prolia far outweigh any benefit especially when people are reporting fractures in spite of taking medicine that is supposed to improve bone health. I don't get the sense of taking this poison.

I have over $29,000 invested in my teeth. I am afraid of this drug and side affects. My doctor insists that this is what I need. I have had only one injection so far and already I am experiencing gum boils and loose gums. I am terrified of what do I do now? S O S I need help and to be informed of my rights due the side affects of Prolia injections! Please somebody out there help me! I do not want to take any drug that is dangerous for me or causes me to loose my teeth and everything I have already invested in trying to save my teeth. Before my first injection my teeth were doing very well, so why did I suddenly start to experience dental problems? I feel angry! I might have other side affects as well throughout my body but my main concern are my teeth and pre existing dental work. Help!

I received the Prolia injection on August 9,2021 to treat osteoporosis. Regrettably, I did not do my research.
At first I was nauseated, then dizzy, 6 weeks in, that I s when I realized the connection, my right thumb became stiff and painful, that is when I started researching what was going on. Now, October 17, 2021, my thumb is useless, my bones crack, joints hurt, ache and stiff all over, just a general depression has come over me. I feel as though I have allowed someone to poison me.
I feel like I have aged 20 years over night!
I will not be receiving another injection and wish I had never tried this! I realize there are some who say this has worked for them, but from what I have researched, maybe 20% benefit. It is NOT worth the gamble!!!
My body have continued to decline and this drug will be in my system for another two months! I just pray that too much damage isn’t taking place.
This is the only time in my life of 63 years that I have wanted to sue anyone! Prolia needs to be off the market!

After having side effects from other bone density drugs, my Dr. said he had a new, very effective drug, 4 shots, one every six months. Had the first one and asked about side effects as I was having bone, muscle and skin pain. He emphatically said it wasn’t the Prolia. Much pain and physical limitations after the second shot. He kept telling me it wasn’t the Prolia, even tho that was the only new drug I was taking. Stupidly believed him. After all, he was the doctor. Got the third shot and discussed it with my primary care dr. She looked up possible side effects on the CDC website. Decided there would be no fourth shot. Dr. got very angry and insisted it wasn’t the Prolia. Changed Dr’s. They then filed for and got the vaccine, which was $181. I called the agency and told them I did not get the fourth shot. What a bunch of incredibly unethical doctors and their support staff. After 3 years, I still cannot function. Get me some money to hire help with my everyday activities.

I have developed hoarseness in my voice. Has this happened to anyone else?

How can I get this Prolia crap drug out of my system, it is destroying me physically and mentally, not to mention my hair is falling out for the 2nd time since chemo? Had 6 shots of this junk so called medicine from 2017 unto 2020. Yes I'm angry!

I had 1 shot of Prolia, March 2017, Was told not many side effects and most people had none. 1 week after shot had (what Dr. said were nerves) nerves going through my body 24/7,never stopped, lasted about 7-8 months, then jaw pain,sticking jaw hard to eat, ears dry and itchy, skin itching still all the time. Then I began to loose strength in arms & legs and balance. Noticed my right breast was increasing in size (now twice as large as my left breast) Went to my Dr. she said “Breast not that much bigger) When I called to make next appointment,was told (SHE CLOSED HER PRACTICE) She was not that old, maybe 50-51. Right side of my body (arm,hand leg all bigger than my left side. Back pain all the time. Lost my ability to walk (have to use cane & hold on to someone or something to walk) Lost my ability to write (hard to even sign a check) This drug has destroyed my health, body & quality of life. I always had good checkups, Nothing changed in my life except taking that 1 shot. This drug should not be on the market and never given to another person

My Mother was given her first Prolia injection in February 2020. She started having severe bone pain about 5 days later she was in and out if the hospital. She then developed a horrible lung infection and could not recover and passed away on April 10th. I do not recommend this drug to anyone!

I had first injection 10/07/19. The first week I had serious joint pain and could not assume usual activities. It is now 3=20. Immune system totally disrupted. Pain in spine, hip, every shoulder and arm joints. Activated immune systen with very severe GERD, fungal infections in nails and esophagus. Nose, throat, dystonia of larynx involved. I was fairly normal previously with many years of bisphosphonate use that built bone. I am 81 and this has ended my professional life which had been prolific

I have been taking prolia injections since 2014 since taking the injections I have had numerous issues with my stomach severepain,nausea ,vomiting .some days I was so weak couldn't get out of bed. I have had several of my teeth bresk apart to point I have lost seven teeth went to dental speciist yesterday going to cost 58,000 to repair the damage done to my teeth. I would never had taken prolia had i known about the horrible side effects of this medication. I am now forced to live with broken and missing teeth due to this horrible medication.

I confess. Had great success in past vcd 20 years with Aredia and Reclast. Finally Reclast stopped working and I was offered Prolia. One injection, 10/97/19, and bone and joint pain kept me in bed 5 days.I have a weak immune system, very low IGA. Since then I have had joint pain, serious reflux esophagitis with no obvious cause, fungal infections in mucous membrane tissues, burning eyes and intermittent incontinence . This is a difficult case to adjudicate but I will when there is a class action lawsuit.

I had 2 doses of polka began having .Many New and increased jaw joint pain throughout my body. Dentists confirmed my jaw and ear was result of taking prolia. Have been suffering from shoulder elbow wrist hand pain loss of strength throughout my body. Arthritis increased in all my joints have had several procedures and shoulder replacement.within last two years as a result recently required treatment in the vertebrae of my neck to alleviate pain. I feel prolia
Has been the cause of all my pain.

I went to er on Augsut 2019 for shortness of breath. Tests were done and referred to cardiologist and pulmonary specialist. After seeing I still have no specific diagnosis. 3 CTS AND chest X-AY WIH LOADS OF BLOOd work. I started on Prolia dec. 2017 after fx left wrist. I had all kinds of effects after injection but doctors did not listen that they all started after the prolia injections and gradually got worst. Now I am in limbo. due for another inj late may.june but will not proceed as I also now have a loose tooth. Have fibromyralgia but increase body pain where I can no longer go out as the pain is so bad. I am writing as physicians do not know what the harm this medication causes and want everyone to be aware. I have been in the medical field for years and feel if the drs were aware they would not ignore my side effects. respectively,

I was injected with Prolia on 9-19-17 and six months later on 3-19-18. After the first injection I was experiencing bones aching, but surmised it was part of the healing process for osteoporosis. I had the second shot with caution. Within a few months the pains and aches in my bones were awful. In getting out of my car on 9-17-18, my leg snapped and I fell to the ground. In the ER it showed a femur hairline fracture and bone bleeding in the knee. I am crippled with bone pain in knees, legs and hands and now having jaw problems. I do have arthritis but until I had Prolia shots, it was not a problem. After seeing the dentists for a root canal they have advised me of the danger of dental work and the fact that the jawbone cannot deal with extractions as the blood supply to the bone has diminished or disappeared. There should be a class-action suit against Prolia and I feel sorry for anyone that has had the adverse reactions that I have had from this poison.

I was given Prolia twice just over two years ago. I am sorry I listened to the Dr that gave it to me saying oh no one has side effects from this. My health now is a mess. Yes my osteoporosis has improved but it seriously damaged my immune system. I don’t know it I will get my health back. The list of side effects is very long.

I was put on Prolia in 2013 two shots a year. My course of injections was stopped in 2018. In March 2019 I suffered excruciating pain. An MRI showed all my vertabrae from number 8 to the base on my spine had compression fractures. My doctor told me he was very sorry.

I had Prolia at the suggestion of my doctor, to help my bones. I was told to get any dental work done before I had the shot. She didn't say why, and no other warnings were given. After the first shot, I noticed my teeth were getting rotten and breaking off. I went to a dentist and he told me he couldn't touch me because I'd had Prolia. I had to go to the Oregon Health Sciences dental clinic, who told me this was a common side effect of Prolia. It's costing me nearly $3,000.00 to get my teeth fixed and I may have to have jaw surgery on top of that, if things go badly. Why is this drug on the market?? It needs to be taken off!

I have lost sleep over all of the comments that I have read on this site and other statistics/data from other sites on Prolia. My doctor recommended this for a shot tomorrow but I am pretty much convinced at this stage of my llfe that the side effects from previous
is probably not worth risking a life of misery. I already have mild Gerd and a history of UTI's and one displaced fracture from osteoperosis but that break was almost 8 years ago. I am currently taking alendronate an Vd3 and a complex vitamin but all of that since the last DEXA. One side of my body showed improvement, the other did not. I won't know about the added D3 improving my osteo until the next DEXA but that has to be 2 years from the previous DEXA to be paid by Medicare? This is a horrific dilemma: risk another fracture or risk untold side effects. The PROLIA website only has women talking about how great this medicine is; no personal stories about problems.

I truly hate Prolia! I have been suffering for over 18 months from this horrible drug! It's totally tore up my sinuses that each month now I go through this Horrible coughing that won't stop unless I go to the Doctor for prednisone. I have copd & never had any type of cough as this. It only started 8-10 days after the first injection....& has continued every since! Jaw pain included...! Every month!!!!! I refused the second injection! Good thing obviously....since it seems this Isn't ever going to wear off! This is every month since going to the Doctor! I get maybe 8-10 days after stopping the prednisone wgen it starts all over again & Won't stop unless I end up at Doctor for medication. Why is something like this even on the market? It causes more harm than good! Hate it & sorry for anyone having taken it loke myself!

I was on Prolia injections for approximately 5 years. The injections did seem to work. I then had to have a tooth extracted on my upper left side and after an agonizing 4 months, it would not heal and was obvious something serious was going on with it. “Something” was coming out of the jawbone, through the gum, swelling my face and scratched the inside of my cheek. I was diagnosed with Osteonecrosis of the Jaw. Bone had to be removed. My teeth are now shifting, appear brittle and I am having to have almost monthly dental work. Since I can’t have extractions, I cannot have implants. The bone in my jaw is always sore and the area on the missing jawbone is very sensitive. The oral surgeon had to leave a jutting bone and this causes pain. My crowns pop off, most of the time my teeth break at the gum line. My dentist and oral surgeon work together to do whatever can be done so that I have teeth on the top. I am 67 years old and have had to spend thousands of dollars on dental work that sometimes doesn’t last. I know that this is going to be ongoing and we have no idea how we will be able to continue “fixing” my teeth, my dentist just does the best she can with the situation I have. My oral surgeon says that this disease is becoming more and more prevalent. I haven’t had a Prolia injection since November, 2017. Please, anyone who gets on these shots, talk with your doctor and an oral surgeon about this. I wished I would have known about this side effect and I would NOT have gone this route. The maker of Prolia is responsible for these side effects and not notifying the public more diligently. As a result, they should be helping us to fix the problem they caused

In the middle of August, 2019, I developed an abscess the size of a baseball on my right jaw. I first went to an Urgent Care, who sent me to a private hospital ER. THAT hospital sent me to a teaching medical center to their team of oral surgeons. I was literally tortured in the ER because they could not deaden it enough to be able to work on it. They then admitted me for
3 days for IV antibiotics and pain control. I am having oral surgery in three days, and I have no idea what to expect afterwards, and I may need even more surgery.
ALL OF THE DOCTORS SAID THIS WAS CAUSED BY PROLIA.
I ONLY HAD 4 INJECTIONS AND WAS DUE FOR ANOTHER ONE.
I AM BEYOND PISSED.

I have been taking Prolia since around 2008, after a rare form of cancer in 2015 I was told to continue this injection. Years ago I started having problems swallowing, choking and went to my GI doctor and he stretched my esophagus, still it continues and I didn't realize until NOW how very dangerous this drug is. I also have extreme fatigue, weakness, breathless after claiming the stairs, bloating, wait again even though I cannot eat at times for the nausea, neck pain with mobility problems that started before 2011, jawl pain that is unbearable with problems opening my mouth to sip tea, pale gums, sweats that are like someone has pour a bucket of water on me, lower back and even lumbar block, the GERD has become worse. I call the manufacturer's adverse reaction department and was told "THERE ARE NO ANTIDOTES" for this drug. What can I do??? I am 72 and no longer want to feel this way, have become basically solitary and do not go out. I need HELP, now.

I was given Prolia on March 5, 2016. On March 10, 2016 I had extreme bone and head pain. Went to ER, my white count was extremely high they suspected spinal menagitis. I had debilitating bone and head pain sent by ambulance immediately to CCF for 5 days. For the next year, I had rashes, bone pain, extremem hip and groin pain. could not eat, my teath were getting loose, my hair was falling out. One week I went to the ER twice in one week because the pain was so bad. I could not sleep because of bone pain, nauseous, I could not think clearly, then I started having really bad back pain, neck had trouble moving my neck. My ankles were in pain, could bareley walk, took pain pills so I could function. I went to work went home and slept without eating for close to a year. Sat at home and had freinds buy my food. I called the manufacturer filed a complaint, went to several doctors, called pharmacists did everything I could, brought ice packs to work, to keep on my hip and groin. I still have major pain in my hip. That shot ruined my health and ruined my every day life.

Prolia has destroyed my life. If you are put on this drug, refuse it. It has changed my life dramatically. I think that it should be taken off the market.
I look like a freak. I had some oral surgery that left my jaw and face knotted up and swollen for months. Then I had an MRI where I had to be anesthetized and I was not told what they do to keep you still and breathing.
I now have a knotted up face with swelling and the most horrible pain that I have ever been in.
I hope that there is a class action lawsuit. I want to get involved in the suit.
This drug is a nightmare!

I have only now connected this drug to feeling so miserable for over a yr. I was getting frustrated with fractures and the dr and I decided this might solve the problem. the symptons are difficult to explain as I thought something else was going on. two weeks ago I personally became so ill that I have been in bed ever since. Did go to the dr and was put on antibotic for UTI. after a week still am ill so I was going back to the my basic health and when I started feeling weak, fatigue pain and my gait was off. not the strength I used to have. I thought it was because my age and have been miserable for awhile. all I am trying to do is feel better and maybe it is not this but going back to my medical history this is the only change and started after getting injections for prolia. If it is nothing then okay but I need to get my body back to healing. Respectively,paula

My Doctor sent me to another Doctor. I had a bone scan in Dec.2018. It cost over 1,500 dollars! Since I was 60 my bones was thin. I was on Fosamax for 2 years. Than my Doctor retired and I got another Doctor in the same building. She than put me on infusion for 2 years that lasted a year. The next time she had another infusion for 2 year. In Dec. 2018 she sent me to another Dr. and they gave me a proila shot. I have been tired all the time and my back hurts and my eyes are getting worse! I have trouble sleeping. I feel worse now and have headaches. She wanted me to get another shot and I said no! I do not have cancer and I read where women was loosing there hair. They treat patients with prolia who have cancer. I changed Doctors. Take it off market! My right foot is numb! The FDA needs to listen and there should be a law settlement!

My doctors at the VA have been encouraging me for several years and I have rejected their advice.
Finaly I made an exective decision and told them I would subject myself to their wishes, but I would like to do some research on denosumab. I am so glad I made that decision, after doing research it will never happen.
I am presently taking Vd3 and calicum twice a day, and the research says that one of the side effects is the deplition of calcium in a persons system. But that isn't the only reason, irecomend a person checks out all of the side effects, and do research on lawsuits that have, and are presently being filed.

I had my first Prolia shot october 2018 and I started to feel pain on my left hip and groin area. After 6 months, in April, i had my second shot of Prolia and a week later started having pain like I had never experienced before. My entire left side, starting in my neck going to my shoulder my ribs, back, hip and knees down to my feet. I can't raise my left foot and i can barely sleep because the pain is so intense. Now I'm having pain on my right side also but not as intense as on the left side. When i went for my second shot I told my Gyno about the symptoms i had experienced and he said to take Tylenol and that those symptoms would go away. I can't sleep unless I take medication but i can barely move in the morning to get out of bed. I can't move my legs they're numb and hurt so bad and my back is on fire. I have an appt to see my dr and see what he may suggest but i truly regret taking those shots, I'm very worried that I may have other horrible symptoms and permanent damage to my body. Please, don't take this terrible drug, u will be poisoned and regret it for the rest of your life, just like me.

This drug just about killed me. completely robbed me of all calcium I cannot get anybody to take this case. I was in the hospital for six straight months my kidneys went from 45% to 4% within the six-month. Of the dang injection. Ruined my life immediately was on dialysis too much later acquired the horrific disease calciphylaxis. If you do not know what calciphylaxis is, look it up please. If you have anybody in your family that you love you need to look this up it can be very deceiving on the diagnosis but if you do your homework you may be able to save your life somebody else's life or your family's life. Need a lawyer I need a punching bag and gloves. Totally upset at the fact that I never heard of any side effects prior to my illness from it. FDA says oh we're not responsible we've said the side effects were this and that. Which is total BS I didn't hear about it till a year later on TV about side effects. The doctor I had conveniently retard to do research at UTMB in Galveston. He suggested that medicine to me and trusting him and him knowing my blood work supposedly I allowed that to happen but I'm also 68 years old at the time seeing a lot of doctors and trusted him now what do I do who do I go to? Does anybody know what I can do to get some of my pain and suffering compensation. I'm on dialysis for life until a kidney transplant maybe even worse because calciphylaxis loves drama and he could very well kill me during the transplant process. Please look up calciphylaxis I beg you

Prolia. The biggest medical mistake I've ever made. I resisted taking any kind of osteoporosis meds because of the suffering I saw my sister go through after Fosamax. Finally, after breaking a couple of bones, I reluctantly opted to take the Prolia injection in the fear that I might break one of my hips, and not before three doctors assured me that I would not experience the jaw/mouth/teeth problems that my sister did. After the first shot, I got a recurrence of the Gerd I had experienced many years before. Only this time it was stronger and more often than before. After the second shot, I was told by my dentists that four teeth in my mouth were loose and had to be extracted at the cost of $13,000+, that cost does not include the implants. I don't know how far this poison in my system is going to go. Right now, I am on the FB Prolia page and what I am reading from Prolia's victims is just frightening and no one seems to know where it will go even after you've stopped taking it. I am also frightened not knowing where my life is going to take me now that I've had two Prolia injections. This stuff is poison/toxic. It's got to be taken off the market or who knows how many more women will suffer from it. That was it for me, NO THIRD SHOT FOR ME OR ANY OSTEOPOROSIS MEDICATIONS EVER AGAIN.

THIS (FOR ME) WAS THE BIGGEST MEDICAL MISTAKE I'VE EVER MADE.......I BEEN THROUGH SEVERAL MEDICAL TRAUMAS AS I AM IN MY UPPER 70'S BUT TAKING 3 SHOTS (AND NO MORE) OF THIS EVIL DRUG HAS TOTAL CHANGED EVERY BODY SYSTEM TO THE NEGATIVE...AVOID AT ALL COST

If not for me, but for every person that is suffering from the horrible side effects due to the drug Prolia.

Update: Prolia. I posted on this site on April 9, 2019 about the terrible side effects I have after taking a shot of Prolia. Today, May 21, 2019 I am still in pain. I still can only drive a short distance because of pain in my right hip, right knee, right ankle. the pain level is between 5 - 6. The pain has changed my life, the pain has not improved since late Jan. 2019. My bones feel like they are burning from the inside of the bones on my right side from hip down, often including my low back. My heart still races often, wonder if that is from Prolia or if the pain makes it race? This shot totally changed my life, in such a bad way. It is a very harmful, dangerous drug.

had mouth ulcers vagiMy life has been ruined by this drug.e.a few weeks latter I had joint and muscular pain.had 3 epidurals with no results.ended up having laminectomy and spinal fusion.after that I had cervical stenosis..my life as I knew it is over.i was an 80 year old.and very fit.the Dr's always stand for the pharmaceutical companies.will not believe my condition was caused by PROLIA "ts a lie.and I cannot afford a lawyer.its so unfortunate. Please do not take this drug.im going to ABC to a survey of 7 on your side.they will only listen to my story, the company Argen are making millions from this awful drug.give it to people with bone cancer not for osteoporosis thanks for listening.

Had one and never again Prolia injection 9/29/18. Was bedridden many months with the worst fatigue ever, severe pain in Colon and stomach, itchy scaly skin patches, ear pain, numbness & tingling in many body parts, severe chills, Arthritic areas swelled up and red with severe pain, knee pain, muscle cramping behind knee, foot, hands, fingers, rib cage, constant loose cough with excessive thick phlegm, multiple stools, excessive urination, bladder pain, neck and shoulder pain, tremors in hand, headaches daily, legs numb at times, 14 lb. weight gain in a week, only able to eat one food at each meal. Nausea and many more. This drug is killing people and needs taken off the market let alone the horrific damage to other's. It has no beneficial effect as was advertised. Amgen owes us !!!!!!!!!!!!! Was in Emergency room with multiple infections and thought I would surely die.

I had Prolila early Aug 2018, within 10 - 14 days pain stated in right arm, then pain went to right hip, low back, right knee, right ankle, right foot and toes. August and September 2018 pain kept me up but was not unbearable, pain level between 5-6. The first week on Oct 2018 the pain was a 10, severe pain, like the bones were burning from the inside out. Nov and Dec 2018 pain continued so severe that I prayed to die, Jan - Today April 9, 2019 the pain continues to be between 5-6. I was not able to drive for most of that time because of the pain in right leg. Now I’m careful not to drive more that a very short distance, That shot has been life changing for me and not in a good way, it’s a very dangerous drug.

I was about to start Prolia on the recommendation of 3 doctors: 2 endocrinologists and an internist. One endocrinologist called me after office hours to tell me his recommendation to start the drug.

The cost of this drug is over 1,000.00 per dose. Still, based on my doctors' recommendations , I was willing to get the shots.

Until I read the internet. Why my doctors said nothing about the side effects of this drug is beyond me.


Thank you all for writing in.

Prolia is an accident waiting to happen. Do Not Take This Drug. After one shot in January 2015, I am still having immune system problems and that has affected my food allergies, headaches, and most importantly has exaggerated my irritable bowel symptoms, I am flung from watery diarrhea to being all bound up for days. I have lost 12 lbs from this diarrhea. Turns out that I had weight loss surgery 40 years ago where my small intestine was shortened, and bowel surgery is one of the contraindications for Prolia. Unfortunately at that time Amgen, the manufacturer, had only a 30 page document on Prolia on the internet and the contraindications were listed in small print on page 14. How was my doctor supposed to know? I hold Amgen responsible. They admit it affects the immune system. It has turned mine upside down and made my life very hard. I can no longer predict when I will have these "prolia spells" where my body is totally inflamed and the diarrhea begins all over again. I have to be very cautious where I go and I never know how my health will be.

Sept, 2018 did first shot. Jan 2019 while walking left knee cap started moving side to side. I sat down on the ground. And could push knee cap around. Went in to shock. Sent to ER. Knee cap had shattered. Surgery, 4 screws and wire. Will never do prolia again. Have other side effects that had been listed. Would love to sue and have this off the market.

I began Prolia 9/7/2018. I have had only one injection. I would never have another. From October until late January, I had severe hip, then groin pain.. Was unable to walk correctly and was confined to sitting or laying down. I could not navigate the stairs in my own home. I had the hip and thigh bone xrayed in November showing no fracture . The pain was almost unbearable. I was taking the maximum doses of Tylenol and/or Bayer Back and Body for about 3 months. I called Amgen, the manufacturer. They were no help. I also phoned FDA and gained a lot of information. My primary care doc. said that the practice had 200 patients and no problems. When I told FDA that I found that hard to believe I was told that they also did not believe that. The FDA gets lots of calls about Prolia and the hip issues. Is the FDA not supposed to protect us? I am now in physical therapy to try to help the pain, the ability to walk correctly and without pain. Also, in the last six weeks I have developed patches of very dry scaley skin on my legs. This is also another effect of Prolia. I have lost 6 months of my life and am hoping that come the 6 month mark, I will be back to some form of normal. This has been a painful, expensive and unnecessary experience that noone should have to endure. Before Prolia I was an extremely active, pain free senior. This drug should NOT be on the market.

About 3 years ago my arthritis doctor suggested I take Prolia injections for the first report I ever had of osteoporosis, rather than osteopenia. I had 2 Prolia injections 6 months apart, then suddenly I developed a right femur fracture leading to bone necrosis and bone collapse, then leading to emergency hip replacement surgery. Ever since I'm crippled and have to walk with a walker or cane at best. Now the femur is acting up again. There was no previous warning that Prolia could do this and I learned about it later when I read up on Prolia. In their explanation of the drug, they mention in very small print later in the write-up that femur fracture is a possible side effect. In their TV ads they never mention this! This is a very dangerous drug and should be taken off the markt.

I recieved . prolia injection in Oct 2016 (cost $3,012,00) Jan.2017 experienced breathing issues, hospitalized . severe lower back joint pain,achy muscles. May 2017 2nd. injection was denied by insurance. . Aug 2017 I suffered a fractured vertebrae ,L 5. my quality of life has been reduced to life care restrictions, and constant pain. Prolia should be removed off the market.

I am a 60 years old female from Denmark. I was diagnosed with Osteoporosis in 2012. I started treatment with inj. Prolia in may 2012 – one shot every 6 months. I recieved this treatment until may 2017 and was expected to pause the treatment to avoid side effects. In connection to this discontinuation of Prolia treatment, I was in november 2017 treated with Aclasta infusion to avoid the discovered rebound effect of discontinuation/pause with Prolia treatment. Despite of this, I shortly after was diagnosed with severe bone loss as a rebound effect of the Prolia pause. Since then I have received preventive treatment with Aclasta infusions 4 times with questionable results. In this last year I have had 3 cases of fractures in my thoracic vertebrae located in T6, T7 and T8. At the hospital I was told, that these fractures were caused by Prolia rebound effect – and I will be in high risk of futher fractures for the rest of my life.
Before 2012 I had a normal family life and worked fulltime as a teaching certified nurse. From 2012 I followed all instructions from the doctors at the hospital, where I was treated. Futhermore I have a healthy lifestyle without smoking or drinking alkohol, my BMI has always been between 22-24 – and I started to run 4 miles every 2nd day to strengthen my bone structure. Now – after Prolia treatment - I have serious backpaines every day preventing me living a full family life, from running and I can not work fulltime any longer – even though I am treated with painkillers 4 times a day.
I am disappointed and angry that the Prolia product was released to the public by Amgen before the rebound effect of discontinuation or pause in treatment was fully researched and described.
I am in pain and despair.
Do You see a way forward in my situation?

Kind regards
Mette Susanne Nielsen

Horrible drug. Severe side effects. More fractures of ribs. Weakness. Fatigue. Feel like entire body is collapsing. Never start it. Please

We are not completing sure if it was the PROLIA that triggered mom's seizure disorder OR the electrolyte imbalance it brought on...OR the flu vaccine...or another med she needs for elimination. BUT noted these symptoms AFTER administration of the shot. Better to build up the immunity with Probiotics, and strengthen the bones with minerals.
The side effects are clearly not worth the risk!

Horrible drug, changed my quality of life. Extreme all over chronic pain, increased with each of the four injections I had. My story is nothing compared to some. This drug should not be on the market. I called Amgen to get statistics on the rebound vertebral fractures that happen when you stop the medication, and the manufacturer has NO stats. This is insane to not track what this drug is doing to people.

My mom was encouraged to take Prolia injections for her low calcium count. Since she has been taking the med she has complained of pain in her back and hips. These has been discounted as "oldage" pain. She has had edema and not really understand why. I was looking up avenues to find ways to pay for her copay today because she was refused the med when we could not pay the $237.00 Co pay today. We asked them to bill it, they refused. We had already delayed the shot because they said they needed approval from the insurance to give it. The first shot that was given did not need all this. I just don't know what to do. Looks like this could be a blessing in disguise. After reading all the problems everyone is having I don't want to see my mom go down hill from not getting her med on time, she is already late taking this med. 2 months because of the run around. This hospital also has taken good care of mom til recently, after they have merged with another company. Please help.

Since taking the Prolia shot in 2014, I have spinal fractures , shrunk 2\12 inches in height, suffered bone and muscle aches, including groin pain and had trouble sleeping because my thigh bones would radiate so much pain. I suffered hair loss and dry skin. My dentist said I have jaw bone deterioration. Even with all these symptoms, my rheumatologist insisted I keep taking Prolia. When I refused, he said he could no longer treat me. Even with insurance, my medical bills for the spinal fractures are extremely high. The pain handicap me. I will never be able to live life without pain.

So, I have been on prolia two + year. I had neck surgery and my fusion did not take. I have burning under my skin in my feet, knees anrms and hands. My hair is falling out and constipation quite often. I am not taking the next shot coming up..

I was given Prolia by injection twice. The first injection was June 2016 and the second injection was December 2016. I suffered from debilitating pain in my arms and legs during this period of time so I refused to have the third injection which was due in June 2017. On October 7, 2017 I had my first spontaneous vertebral fracture. I continued to have more spontaneous vertebral fractures until Oct. 1, 2018. I have had a total of seven. T11, T12, L1, L2, L3, L4, and L5. My quality of life has suffered greatly due to these fractures and I can not stand up or walk any longer than around 30 minuets and then I am in extreme pain. I don't believe this drug. should still be on the market. It has ruined my quality of life.

I had 3 shots of Prolia in 18mths and just before I was to do the 4th. I developed osteocranocis and now all if my teeth have destroyed..

After numerous stress fractures, the last being fractured pelvic and pubic bone I was diagnose with severe osteoporosis and placed on daily stomach injections of Forteo which did the job NO more osteo but in order to hold the bone restoration place of Prolia injection every 6 months for the next 5 years. During this time I have had severe diarrhea leading up to emergency small bowel obstruction surgery that nearly me my life. NOW I am plagued with a worse cause diarrhea.

I started on Prolia 3 or 4 years ago but didn't have problems until the 3rd injection which put me flat on my back for a day or two. Then I was sick for 2 1/2 weeks.

Now my bone density is screwed up again with bone fractures...

Guess I'll go back to Forteo. But not before doing another google search.

Best of luck to all who have had problems.

I now have TMJ due to a featured jaw bone which I believe are from PROLEA injections going back to 2016. My PCP suggested that after my bone density showed ostopenia. I voiced my concerns after hearing the Proleia TV ads warning cautioning about the injection especially for people with low calcium. He reassured me there nothing to worry about. 1st injection was spring of 2017... 2nd was end of 2017 when I also received a call from PCP's office that he wanted me to start taking 3000 calcium a day. Started to have jaw pain and that is when I got an xray and the diagnosis.

I see my comments are now up along with updated ones. Thank you. I was wondering why I saw no current comments before now. I wish someone would tell us what we can do. I don't think FDA cares enough to take this drug off the market and my oncologist was not listening to me. He told me "Don't read the forums" and implied they were all crazy people producing mass hysteria with their ignorant comments that I was reading. I would never have allowed this drug in my body (with having only osteopenia and told it would be helpful while on estrogen blocker) if I had known it was used as a chemo drug. I think many doctors are not informed. IT's there job to be informed, yet my doctor discourage me from reading comments like the ones posted here. From what I am seeing, dentists are the ones who seem to be understanding better the bad results of Prolia. This stuff about "it leaves your system" is hogwash!! After two months since time to get my 5th injection (which I did not show up for) I am still dizzy and having mouth problems.

Had my first shot in October 2018.I have been experiencing pain in all my joints with swelling in my right hand.Got a bladder infection in December.The pain has caused me to use a cane off and on,I can't turn my head to the right.I take Aleve twice a day and that doesn't even help.I can't sleep and constantly feel confused.Now I have a respiratory infection.My Dr looks at me like I'm a crazy frequent flyer into her office these days.There will be no more of this drug for me!

I have severe osteoporosis and have had multiple fractures over the years. I also have mixed connective tissue disease with severe arthritis and Sjogren’s Syndrome. After my first Prolia injection in fall 2016, the dry mouth worsened tenfold, and it was already horrid. I developed a UTI after each of my 3 injections, and my endocrinologist and PCP discontinued treatment due to my allergies to antibiotics. Now, a year since my last injection, I have terrible gum and teeth issues my dentist blames on Prolia. I’m 61 and have always had healthy teeth. Suddenly...I don’t.

I do not see my comment i made last week and I notice that comments have stopped as of July 28 and that a legal firm has also stopped taking on clients. Nobody called me when I applied for help about my side effects. ARe people being hushed up?? This is a seriously bad drug!

Further to my post dated April 3 2018 tabling a set of worrisome adverse side effects data drawn on Prolia Leaflet itself, and advising my wife not to continue with it after taking her first shot mid November 2017, I am now reassured to read the following extracted from a summary research report on Prolia titled ‘Denosumab: Immune dysfunction’ dated November 2018, issued by Prescrire – an internationally recognized French Medical Journal:
“As expected from the pre-market evaluation of denosumab, reports of adverse reactions related to disruption of the immune system attributed to denosumab are accumulating. To date, several thousand cases had been recorded worldwide. Before and after its commercialisation, an increased risk of deep infections (heart, brain, bone, skin, blood) was observed with denosumab as well as an increase in cancers. Severe hypersensitivities, and sometimes serious or even fatal autoimmune disorders, have been observed.
These disruptions to the immune system are in addition to various known adverse effects of denosumab: back pain, muscle and bone pain; hypercholesterolemia, hypocalcaemia, osteonecrosis; bone disorders and atypical fractures. There is also a risk of multiple vertebral fractures when treatment is halted.
The harm-benefit balance of denosumab is clearly unfavourable in osteoporosis. It is better not to start such a treatment, which also avoids any problems related to halting it.”

I started Prolia after treatment for chemo which I was diagnosed by taking chemo for breast cancer. I have one injection which caused cellulitis in my left arm. I started having pain all over. I was falling a lot then started losing teeth 3 so far. I am just wreck right now. Wished I have never seen or heard of Prolia. Do not listen to the commercials on TV regarding this dangerst drug.

I am having the same reaction as Mona Jensen above. Salty or other weird tastes that vary a little bit depending on how much my body is "surging" that day. I call it the prolia surge for want of a better term. I feel some kind of surging inside my body a little like spinning inside me. Vertigo? I do not know what it is. The sores come and go but the worst of all is that it affects my lips and I am constantly having to chew gum, otherwise, I am sucking up saliva from my underlip. I have seen numerous doctors. Not one can help me. I started Prolia because a bone span said I had osteopenia and would need "help" for my bones while on estrogen blocker. Well, after the fourth injection is when things really heated up. My tongue even turned red and I was told I had "hidden yeast infection. I did not go back for injection #5 . As of Oct 16 I had hoped it would be out of my system. A natural doctor is having me detox, but that's not working. Thanks alot, Prolia!!

My mother was on dialyses and died 6 months after the first shot.
This was given for osteoporosis. My mother refused the Prolia but the doctor insist en gave er these deadly shot.

They killed my mother!

I had thyroid surgery in 2014. In 2017 I was diagnosed with osteoporosis and prescribed Prolia. Had one injection in June of 2017 and another in December. After the 2nd shot my voice became horse, my rheumatologist and endocrinologist deny that it could be the Prolia. By October 2018 I was diagnosed with cancer. I should have NEVER been given the drug. Physicians were irresponsible. Get the DRUG off the market. If it works for you, that's GREAT but it should not be given to others.

After reading this, I am wondering why this drug is still on the market. My mother was advised by her doctor to get the Prolia shot for osteoporosis. Her first shot was in February of 2018. Since then her health has steadily deteriorated. The first stop was to a dentist for jaw pain. Finding nothing there, the pain continued, so her doctor prescribed meds. The right side of her face started swelling. After several months and yet another trip to the ER, an ENT was finally called in and he performed a biopsy. He continued working with her and found that her jaw bone had deteriorated and had a hole. Right now she is on daily antibiotics as he tries to fix the issues caused by the Prolia shot. If this doesn't work she's looking at a jaw replacement. Enough is enough with this drug!

The worse year of. My life. Excruciating pain in groin thigh back ribs shoulder blades neck and jaw. I am wobbly when i walk. I have lost muscle strength due to inactivity. I had to go back to the walker 3 times. I had 5 shots with the last one on JAN 8 2018. I was not informed much about it just that i needed it. MY BIG MISTAKE!!!
I have had Thyroid (Graves’ disease) and kidney and should never have been prescribed to me. Please take this horrible pain from me.
I am losing my life and indepentance...

I have had two Prolia shots 6/17 & 12/17. My rheumatologist never discussed side effects, even when I questioned it. Never offered me any literature or to connect to the Amgen patient program. Prolia would be good for my bones, reducing my calcium level even though I had had my thyroid removed. After the second shot, my voice began getting horse and by 2/18 I was diagnosed with a paralyzed vocal cord. Between my GP, endocrinologist, ENT no one picked up on the lump in my neck which needs to be surgically removed in addition to other parts of my neck. My voice is a low gravel sound. No way to prove that is was Prolia but I wish I had listened to my gut and refused to take the shots. Just a casualty of let's see if this works. I truly feel that the medical profession and my doctors did the right thing for me. Once again, you need to be your own best doctor. They are too willing to give out medication at our expense.

Worse drug ever!! I have had extreme fatigue , stomach issues with vomiting , back, leg and hip pain, mouth blisters, hair loss and splitting finger and toe nails as well as dizziness . I was not told about the rebound fractures if I stopped this drug. I have had 4 injections with side effects increasing and lasting longer with each dose. Thank you

This drug Prolia is such a horrible drug ! It never should have been approved ! Have had one injection 5 mos ago . Have suffered terribly right after inj, like bone pain, nausea, also hair loss etc. Since then still have a lot of hair loss, headaches, ear pain, fatique, ear pain ,over all body pain ! Am due to have another inj in a month . Lately bone pain has come back !! Afraid to have the inj but know if I don't I will have rebound fractures along with other problems .
I was told by the Nurse giving it "Make sure you brush your teeth twice a day" .That was the only side effect I was told about !

I started taking Prolia in 2015, I had three shots, the muscle and bone pain for months after this shot are horrible. Then in Oct 2017 I was diagnosed with Medullary thyroid cancer, this cancer is caused by radiation exposure or genetic mutation. I have had no exposure to radiation and my genetic testing game back negative for a genetic mutaion so my cancer was listed as spontaneous. I stopped taking this shot bc I believe this drug caused my cancer, last shot was Oct 2017. L ast month I had serious back pain and after a week went to the ER to find out that I had a rebound fracture in my back, at the same time I found out I have a tumor in my kidney, too new to know the cause. I have been so tired, sick and in pain since I stopped this shot and its continuing. I have nothing good to say about this drug.

J'ai eu ma seule et unique injection de Prolia en octobre 2017.
Depuis, une douleur à la hanche gauche et sur le devant des 2 cuisses. La douleur à la hanche me réveille la nuit et m'empêche de dormir. Je regrette d'avoir fait cette injection mais à l'époque je ne connaissais pas les effets du Prolia.
J'ai consulté une naturopathe et prends un traitement naturel.
J'espère que ces douleurs vont cesser.

I have had three Prolia injections, the first received in June of 2017, the latest in June of this year. None of the literature presented to me indicated that Prolia was a chemotherapy drug. As a breast cancer survivor, had I known, I never would have agreed to this treatment. I have suffered throughout from fatigue which requires me to lie down periodically to get through the day. Before Prolia, I walked four miles every day. Within months, I started experiencing pain in my knees, and now I cannot walk very far and the mildest exercise brings on elevated pain, strong enough to interfere with sleep. I had a severe vertigo episode with vomiting shortly after the second injection. The dizziness and vertigo did not completely subside for six to eight weeks. Since it happened during flu season this year, I thought it might have been the flu, but my internist ruled that out. Now my hair is falling out and eye brows and eye lashes are thinning. I shaved my legs at the start of the summer, and nothing has grown back in. I also developed a cough that was concerning given my cancer history. A chest x-ray ruled that out and allergy testing ruled out allergies. It was determined that I have acid reflux. And somehow I lost 1/2 inch in height in six months. Except for the fatigue and hair loss experienced when I had chemotherapy for breast cancer, I have never experienced any of these ailments ever before in my life, and it's no coincidence that a new malady presents itself every month or so. I have always been extremely healthy, and this drug has stolen my quality of life. I would rather have dealt with the osteoporosis consequences than to have submitted myself to string of side effects that have occurred over the past year. Oh, and add depression to the list. I just feel so defeated with my situation, and to know I have this poison in my system and can't do anything about it. Now I am reading that I have to deal with rebound effect if I stop?? Fractures caused by ceasing Prolia??

Extreme dental problems to the extent of losing all of my upper teeth. I ask my MD when I started with problems if prolix could have caused the problem. His response to me was oh no. My Dentist ask me if I was taking Prolia, because he had seen this in the lower jaw, but never in the top. Please reconsider taking this drug!

I had my first Prolia injection in June 2017 after having an emergency hip replacement from a fall. The surgeon said my osteoporosis is so severe that I was just going to keep breaking bones unless I did something. I had previously broken my right ankle, my right and left wrists and my humerous bone and have a huge plate due to that break. So my doctor suggested Prolia and had some muscle and bone pain from it, but a bone density test 6 months later showed an improvement in bone mass of 9% so I went ahead and got a second injection in January 2018. This time the knee, leg and arm pain was severe--some days I can barely walk and am up and down all night due to the pain. I am 76 and feel I have really lost any kind of a normal life. I have called Amgen twice and they did not offer anything but said these things would not be permanent. I also have no energy and can barely do basic housekeeping. Prescription pain meds don't get rid of the pain, but enable me to function somewhat. My second bone density test 6 months after the 2nd injection actually showed a loss of 3% in bone density. This med should be taken off of the market.

My mother was on Prolia and her teeth started to fall out. She had most of them pulled and now has severe ONJ. She is in constant, excruciating pain and doctors seem to be clueless so far on how to herlp her.

I have been on Prolia for2 1/2 years and the first thing I noticed was the itching, my head, face, arms and legs then about 6 months ago I noticed the hair loss but even worse was the pain in my back, hips and the exhaustion and weakness of body and legs very difficult walking. That first time that I had the itching I asked the nurse who gave me the shot if anyone else had complained about side effects and she said no so I just kept on getting it but when I see these comments I am sure I will not take this shot again..If there is a class action suit since I am in Canada I probably wouldn't be allowed to be a part of it, if not, I wish all you people in the U.S. the best of luck with it and our doctors will see that we are not making that stuff up.
I can't believe how horrible I feel all the time, time to quit it.
Your captcha doesn't work for me

I had my third Prolia Injection on May 10, 2018. On May 11 I awoke with sudden hearing loss on my left ear. I also have vertigo upon arising from a lying position. Prescribing physician said there was never a complaint about hearing loss and so it is unrelated. ENT prescribed Prednisone 10 mg for 10 days. He wanted to do further steroid injections into the eardrum. But the cure rate is only 30% and the treatment is very painful, unpleasant and has side effects. I chose not to be treated. The Dr said there was nothing else he could do. I am writing this July 28, 2018. The hearing is no better. I am now deaf in one ear and will be probably for the rest of my life. My PCP says it is probably an allergic reaction to Prolia.

I'm 58 yrs old and took Prolia back in Jan 2018 and by the end of month I had a left sides stroke. No predisposed situation for the stroke I am now in recovery and have recently been diagnose with vascular dementia. I had researched and read everything there was.

I never had good teeth and lost all the bottom molars which I replaced with implants in 2014. I have serious osteoporosis and am 82, so my doctor put me on ProLia. I had 2 injections in 2017 and one in 2018 so far.
January of 2018, my dentist found 5 cavities in my bottom front teeth. I had those filled in February. In June, I had to have a root canal for one of them. In July, my dentist noticed 2 more cavities plus put watches on 3 more. I haven't had a cavity in over 25 years prior to ProLia. In the FDA study just a few(182 out of 50,020)reported dental caries (study 6-2018) Guess what - for people over 60 years old 84.25% of them had dental caries. So I wouldn't recommend it for people over 60 years old. I had it and I know.

On 10/12/17 I saw a Physician and Nurse Practitioner at a FL spine clinic. I am a Caucasian woman and will be 89 on 7/26/2018.
I was referred by the doctor who had performed my rt. knee replacement in 2003. I was having rt. leg pains, along with back pains caused by a spine compression from a fall in 2017. He recommended that I go to the spine center. Later, the back pain was alleviated by Krphoplasty surgery elsewhere.
At the Clinic I had a bone density test that indicated Osteopenia. At my next appointment the NP recommended I use Prolia for bone health. My insurance company denied coverage. Before my next appointment, the NP obtained 6 mo injections at the Clinic covered by the Amgen, Inc. at no cost. I was given my only injection 11/21/17.

As noted on health history at the Clinic, I had had 2 parathyroids removed on 2005, and now take Methimazole (5mg). As shown on the Prolia website, I should have been been cautioned about Prolia because of my thyroid condition.

From the Website - "Before taking Prolia®, tell your doctor if you:
? Take the medicine XGEVA® (denosumab)
? Have low blood calcium
? Cannot take daily calcium and vitamin D
# Had parathyroid or thyroid surgery (glands located
in your neck)
? Have been told you have trouble absorbing minerals
in your stomach or intestines (malabsorption
syndrome)
? Have kidney problems or are on kidney dialysis
? Plan to have dental surgery or teeth removed
? Are pregnant or plan to become pregnant
? Are breast-feeding or plan to breast-feed."

After taking Prolia I have had these symptoms:

extreme flu-like aches, stomach distress, alternating diarrhea/constipation, stomach acids, sudden hair loss, nail splitting, overly dry skin, sinus congestion with ear pain, along with long-term dizziness and lightheadedness.

I have elected not to have a second injection. I continue to have severe overall bone and muscle aches and the same listed symptoms to a lesser degree.

Worst drug on the market; belongs in a class action suit, seems to be nothing more than poison. Do not use this drug, you will never benefit from it,, I will be sorry for the rest of my life, it robs you of everything, even a simple smile!

nanciann56@gmail.com
I had one injection after my physician and I discussed the possible advertised benefits from this drug, my bone density scan had showed a substantial decline over past years.
Within 2 weeks I had extreme tiredness, I could barely get out of bed. I have had arthritis and back pain the pain tripled, it was so debilitating I could not stand, my hips felt locked in pain and I could not move them, my right shoulder rotator cuff was frozen in place and I could not bear to pick up anything over 2 pounds. Within 3 weeks my hair began falling out, not just regular hair loss or even exaggerated hair loss like you see after having a baby. This was handfuls of hair like you see with chemo or radiation therapy. I lost over half the hair on my head with in 2 weeks. Then my teeth started breaking off. I had just had a check up and cleaning with X-rays in December with no problems. Two molars broke off under a bridge, I can not have tooth surgery to fix with crowns or root canal as no dentist will touch them because I’ve had Prolia. I finally after 6 month have had a crown put over one and I’ll have to try and find a dentist to take the other out. Last night I bit into a soft peach and a piece of my front tooth on the bottom snapped off.
I have had and continue to have excruciating bone, leg, neck shoulder pain. I also have continued itching and rashes unexplained.
As I stand here this morning I am having difficulty holding a thin IPad from pain, I would never take this drug again it should be banned from the market.

PROLIA, horrible drug continues to be a nightmare for me! I am struggling with peripheral neuropathy! It never ends, what next!!! My overall health has steadily declined since the Prolia ( denosumab ) injections. It is now being used for bone cancer!! That alone should say enough about this drug. Hate that I was not informed of all the horrible side effects before taking it! Thanks and hope this post helps others.

This is by far the worst thing that could have been done to my body. I have lost the last four months and have no idea how much longer it will last. I have suffered from shortness of breath, nausea, low blood pressure, extreme pain, swelling of legs and all joints, exacerbated migraines, etc. Total inability to do things I could do prior to February 15, 2018. This is a dangerous drug and something needs to be done to educate the doctors and to get it off the market.

3 weeks after receiving my second Prolia shot I started having a metallic taste in my mouth. I have also got canckers in my mouth a swollen tongue and a nasty salty taste to go along with everything else . I am on my second round of Doxycicaline and although it seems to be working I still have sores in my mouth that will be move from side to side and just aren’t getting better. I am positive it is from the Prolia because I remember getting the metallic taste with the first injection but it didn’t develop into these sores . I will never have a another prolia injection . I also developed a bad swollen ankle that the doctor just said he didn’t know why , take ibuprofen .

Prolia has been an absolute nightmare for me. I wish I had been told by my oncologist about all of the horrible side effects. After surviving 7 injections, and my health rapidly declining, I began to research this horrible drug, denosumab , AKA Prolia, and found out I was suffering from almost all of the side effects. My last injection was in 2015 and I am still suffering and my health continues to decline rapidly. And I cannot find anything to help reverse the damag it has done to me! Poison drug. Should be taken off the market. I post this information in hopes that it will help others not to be a victim like I am. Waiting on a class action law suit. Hope one comes soon.

I had seven injections of Prolia without being informed of the horrible side effects of the drug. I trusted my doctor and didn't do any research myself. I had my first injection in 2012, only two years after Prolia was approved for marketing. My last shot was in 2015, after my eyes were opened and I began researching Prolia(Denosumab). The effects of this drug have been and still are a nightmare for me. I am still suffering from most all of the horrible side effects, and not sure I will ever be the same. It is now being used for bone cancer patients!! As I said, an absolute nightmare for me and I hope I will live to see a class action lawsuit. I have reported it to the FDA,to no avail. As I said before, I am still suffering from the horrible side effects of PROLIA.

I have had two Prolia shots and have never suffered so much in my life. I am 9 months out from the last shot and still hurt, am exhausted all the time, have trouble walking and sometimes have to use a walker or cane which I never had to do before I had these Prolia shots, I have had one tooth break and developed decay under two capped teeth that are part of a bridge so now I have the expense of replacing the bridge. I have hurt so badly in my muscles, back, and legs that I could hardly stand it at times. I resent it that my doctor insisted that I get these shots and did not give me any information about it until AFTER the second shot. I should have done more research but I trusted my doctor. I feel this medication is poison and should be off the market. It has taken my life away from me. Please let me know if there is ever any litigation over this poisonous drug.

Have had three Prolia injections so far. The side effects have been mild to moderate. They have included occasional, mild to severe muscle and joint pains, insomnia, palpitations, fatigue, apathy, and irritability. I was not experiencing these before the injections. The side effects have lasted for about two months after each injection and then they fade out and then I feel normal again. Do not yet know if bone density has improved. Would like to come off of it, but am afraid of the rebound effects now that there are reports of multiple fractures occurring within months or years of coming off it. My rheumalogist suggested Zoledronate injections for when I stop the Prolia, but a recent Science Daily article featured research showing that even Zoledronate does not stop the rebound effects!! How do I get off it safely ????

I had a shot of Prolia Feb 2017 and started hAving pain in my hip and both legs Soon after. Before having this shot, I was walking 2 or more miles most days. As of today, over a year later, I can't walk more then half a mile without being in pain.
Please, if your reading this, do not take This drug.

My GP has really been urging me to take Prolia, since alendronate (generic for Fosamax) is causing bad stomach acid. I have resisted (and also stopped the alendronate for now). Then my GYN urged me to take Prolia and gave me a brochure (which only scared me more). Then ... I saw a rheumatologist for arthritis in one hand, and when I asked him what he recommended for osteoporosis, he said Prolia, too! I'm 67 and in reasonably good health otherwise. These doctors all pooh-pooh my concerns and make me feel crazy for refusing this "wonder!" drug. Just when I'm about to give in, I find a site like this. Thank you all for sharing your sad, sad tales. My heart goes out to you. I wish you speedy recovery.

My rheumatologist strongly urged me to get treatment with Prolia without educating me on possible side effects. I was receiving steroidal injections in both thumb joints a week later and experiencing increased pain I that area. I firmly believe this medication is working against the side effects of prolia. The arthritic pain has extremely worsened after one injecttion. Very concerned about further side efffects since I plan to discontinue treatment after one shot. Interested in FDA making it mandatory for doctors to show video to patients before they have you sign a non informed consent poor medical practice.

My wife aged 61, with no osteoporotic fracture history, and impaired immunity system (RA/RF positive) took her first Prolia shot of Prolia November last year. There has been no side-effects at all. As this medication is practically for life, and can have potential long term effects and escalating cost (that even today is very high) I did the following close scrutiny of the Prolia comprehensive data sheet, date of revision, May 2016, bar code no: 1014678 – that was inside the Prolia carton.
The following of its statements appeared worrisome:
1. “Prolia is indicated for treatment of postmenopausal women with osteoporosis with history of osteoporotic fracture or who have failed /intolerant to other osteoporosis therapy.”
2. “Patients with impaired immunity system may be at increased risk of serious infections…. Consider the benefit-risk profile in such patients before treating with Prolia.”
3. “In a large clinical trial of over 7800 women with postmenopausal osteoporosis, epidermal and dermal events such as dermatitis, eczema and rashes occurred at significantly higher rate than in the Prolia group …Consider discontinuing Prolia if severe symptoms develop.”
4. “Avoid invasive dental procedures during treatment with Prolia”
5. “In clinical trials in women with postmen. Osteoporosis, treatment with Prolia resulted in significant suppression of bone remodeling … The long term consequences of the degree of remodeling may contribute to adverse outcomes such as ostenocrosis of jaws.”
2. The following comment under ‘Clinical Trial’ heading caused me even greater alarm as I attempted to fully interpret them:
“Adverse reactions are listed below by MedDRA body system organ class and by frequency. The frequency categories based on one year event rates ( a patient under one year of Prolia medication) are”:

“Very common …… >1in 10”

“Common…………. >1-100 and < 1 in 10”.

Objective Interpretation of the above clinical trial data:
Since the data is based on one year event rate, if a patient was to remain under Prolia medication for a decade, her odds of facing adverse reaction may be 100%.
The background of this commentator is not important as he has only used the data provided in the referenced comprehensive data sheet that came with the Prolia carton. Any commentator is welcome to spot any flaw in this summary report, prepared with great caution and deliberation, though like any work of man it cannot claim to be immune to human error.
The current and potential users of Prolia must take their own decision whether to start or continue with it depending on their age and risk assessment. This commentator is advising his wife not to continue with it (not to take the second shot due in mid May) as simply because she is too young for this strong injection which is associated with so many risks as its comprehensive data sheet indicates.

I have been taking prolia for two years. I wish I would have checked out the side effects. I recently got a shot less than two months ago. I now have burning in my muscles. Both hands and arms. I have tried everything and no relief. My Dr says one should not take prolia more than two years. My hips hurt, left knee, constantly having inflammation in my body. Anywhere I had previous surgery affecting any bones hurts. Two neck surgeries, broken arm, bunion surgeries, all hurt. I could not figure out why! Extremely dry skin and hair. Never experienced that before. All of a sudden weight gain although I have not changed my eating habits.I eat two meals a day and no eating after 6 pm. I will not take any more shots.....

I received the Prolia injection May 2017. I started out losing my voice and a very, very severe stomach pain. I then developed bad pain in both hippos, legs and right knee. I have fallen a couple times because my knee just gave out and now I use a cane or walker if I have bad pain. A couple weeks later, my lower back started, as well as, right shoulder and both arms., elbows burn off and on. Very, very hard to get any sleep because of pain, even with pain meds. Instead of being very active now, I just want to stay in bed because I have no energy to do anything anymore. I have had breast cancer but I am losing more hair now from this Prolia than I did then.

I have kidney problems, eyes have changed a lot, jaw pain, mouth blisters, problems with my teeth and tongue at times.
I have the worse headaches that I have ever had in my life. My husband just stays by my side until it goes away. He says that I am very confused and I don't even know how to get to the bathroom by myself. He says that I cry all the time because of the severity of the pain and I don't ever realize it. I usually have about 2 a week and I really dread this.

My husband and I worked very hard for 40 years to prepare for a good retirement and needless to say, PROLIA has really ruined that plan and I hope that I can get something back from them. They should have to pay for all of the agony that I have gone through and all of the many, many others.

On prolia for 18 plus months. Have experienced multiple dental problems - as well as constant exhaustion and flu like symptoms. My hair has also changed texture completely - extremely dry. I am now at the point of having to lie down every day for hours to get through my daily routine. This drug has ruined my life. I was a vibrant active person and know I feel like I have aged 20 years. I wish I never took this awful drug!

There is a facebook group for all interested/suffering from Prolia. Please join, people need to know what a poison this really is. I don’t know how FDA and Amgen can sleep knowing they are killing people

Wish I had known about the risk I was taking by getting Prolia shots for 4 1/2 years. I have experienced most of the side effects others have. I am laying here with 2 vertebrae fractures.

After taking 2 Prolia shots in 2016, I developed 14 cavities and had to have two teeth extracted in 2017. After my regular dental checkup in 2/18 I now have 4 cavities under crowns. Crowns will have to be removed and cavities filled. Then new crowns. Possibly more root canals. This has been painful and expensive. I do have Rheumatoid and Osteo Arthritis, have had two knee replacements and two back surgeries. Since I have pain with this disease and previous surgeries, I have pain most of the time. Have to take various medications including infusions for RA. I don't know if some of my pain and exhaustion is related to Prolia or other problems. All I know is I have a lot of pain in back and legs and tired all the time. I have had therapy, massages and use medical taping on back and nothing really relieves pain. This is very frustrating. Dentist knew about side affects of Prolia, but Rheumatologist has not stated problems were related to Prolia.

I was given my first and only injection of Prolia a year ago. After receiving the injection, i started having pain in both hips, back and both femurs. The pain is more severe in my left hip. My doctor said that she only knew of only one other person that had any side effects from taking Prolia. I was never told of the terrible side effects that Prolia could cause. I blame myself in not researching this drug before my injection. If I had known of the horrible side effects, I would never had taken this horrible drug. My doctor doesn't know when or if ever these side effects,
that I'm experiencing, will go away. I have told all my friends to never take this drug.

Apparently, "loose teeth" I have shrunk 2" and my right Shoulder Cuff should be replaced. I have all reports from the doctors and Xrays to show the damage that prolia has done to my teeth (now I cannot ever have any metal touch my gums - my teeth broke in pieces). The Endocronologist wrote a report to my Health Administrators and I had to pay $3500.00 to buy a bridge to replace the teeth that were good - nothing wrong with them.

I'm relieved to find this page. I had my one and only Prolia injection almost 3 months ago. I've experienced a stream of adverse reactions. Unfortunately I wasn't in the best shape to start with. The first extreme problem I experienced, which may have been exaggerated by my medication, was a chronic bowel blockage which resulted in an extremely painful anal tear. Next was an uncomfortable uterine discharge. Followed closely by 2 UTIs and 3 antibiotic treatments. I now have an increase in my complete body pain levels and my front molars, which have fillings, are becoming increasingly painful, particulary when I eat. I now also have to take a pill to relax my bladder muscle so I can pee. There has been an increase in the extension of my uterine prolapse. All of this is accompanied with fatigue and depression. Of course the distributor doesn't recognise any of these side effects.
Another Australian victim.

My bone density results came back osteoporosis in 2012 my doctor prescribed prolia every 6 months ,which i took for 5 years. I woke up one morning in FEBRUARY 2016 and could not get out of bed my hips were locked up and i had back fractures at L 1 was in a back brace while they were trying to figure out what was wrong had surgery at the L 1 had more fractures T 4-T6 and T8-t9 WITH comprehension loss throughout the last two years i am still in a back brace going to physical therapy 2 times aa week and my bone density i just took December 4 2016 was worse yet ,my arms and my hips are in constant pain ,before these company's are allowed to put something on the market to help people they should be sure beyond a doubt that it will help and not add to the problem . I have been in constant pain and fracture a bone every time i do the least little thing it has been a night mare ever since i took the prolia it. Made my bones weaker not better as it was suppose to do i went from dancing 3 nights a week to no social life at all

Prolia has ruined my life. I had one shot in June of 2016 and am still suffering from a long list of side effects as mentioned by all your postings. Realizing that this drug may never leave my body I have fallen into depression and some days just don't want to live anymore. I was a pretty active, social and fun person. Now all that is changed. My Dr refuses to acknowledge that my side effects are from Prolia and I have had every test know to the medical community. He has given me every pain medication including Opiods and Narcotics. They don't work so I don't take them. What does that tell you when the strongest pain meds don't work???
I was unable to eat for months. I lost 20 lbs and looked like a skeleton. I am petite, only 5'1.1/2 in. Not eating made me weak and frail. I am just now beginning to eat although small amounts and have gained 5 lbs. I suffered from horrible stomach pain. I contacted Amgen but that was useless. This drug is POISON. My goal is to inform and get it taken off the market so other people don't suffer.

Had my one and only prolix shot in June of 2017. Should have done my research, but trusted the doctor . Unfortunately he did not tell me about the negative side effects; only spoke about the benefits. Four days after the shot got 4 rashes on abdominal area that lasted few hours. Called dr. And let him know. His response was "its nothing ", if it was a reaction it would have happened sooner. Within a month I started losing my hair. Within two months neck pain, shoulder pain groin pain. When I turned my head it sounds like Velcro. Back thighs are weak. Decided never to take again. It's been one month that I'm off this horrible poison and now I am having very weak and achey front thighs. Still have neck and shoulder pain. I called the Amgen company to ask about how long the side effects last, but could not get a definitive answer. If there is a class action suit I'm in!!! I'm thoroughly discusted
and very afraid of long term effects. If ANYONE out there know about when this drugs side effects will go away, please contact me. Thankfully, barb

rxlist.com/prolia-drug/patient-images-side-effects.htm "loose teeth" I have shrunk 2" and my right Shoulder Cuff should be replaced. I have all reports from the doctors and Xrays to show the damage that Prolia 60mg injections has done to my teeth (now I cannot ever have any metal touch my gums - my teeth broke in pieces). The Endocronologist wrote a report to my Health Administrators and I had to pay $3500.00 to buy a bridge to replace the teeth that were good - nothing wrong with them.

I had Prolia injections every 6 mos starting 8/14 and had last one 2/17. In April, 2017, I had a tooth pulled so I could get a bridge on the upper right side of my jaw. It wouldn't heal and kept leaking white liquid (bone?). In July, went to endodontist who did CT scan and said I had ONJ. I then saw an oral surgeon who agreed and has been seeing me monthly to check healing of the socket. He said after possibly one year, the Prolia would be out of my system and my bone would begin to create new bone tissue on its own. I've had two tiny pieces of bone come through the gum near the socket and fall out. It's now Dec, 9 months later and its better but not healed enough to close the socket with a permanent bridge so I can't chew on the right and my jaw muscles are straining trying to cope. Now I need a root canal on a nearby tooth and don't dare traumatize the jaw so I wait. This stupid med has changed my life and if I could sue I would.

I had one prolia shot eight months ago, I developed severe muscle cramps in my shoulders, hands, feet and tounge of all places, I became so fatiuged I could not walk across the room. To this day my feet hands and lips tingle, hurt and are numb. It is hard to imagine pain in the bones but my feet and hand bones have become very painful. I still have severe fatiuge. When will it end? My Dr. said by six months, but this has not been the case. Are there attorneys that can handle this sort of thing?

I have had 2 prolia shots. After the second shot on December 12, 2016 I suffered SEVERE hip pain almost immediately.
I was used to walking over 5 miles every day. I could hardly walk to the restroom. Within a couple of weeks I noticed massive amounts of hair loss.
Almost a year later, hip pain is better so I am back to daily walks often with the help of over the counter pain reliever.
What is left of my hair, is still falling out with no sign of regrowth. Since taking Prolia my cholesterol is now high. This drug has definately effected my quality of life.
I will never take Prolia again.
I am 62 years old and have always been fit and had excellent health.

Heard a recent commercial with Blythe Danner, at then end I heard the words--side effect--voice problem. Well I don't know when exactly yet I started the Prolia. But I remember in Jan 2010 we went to Vanderbilt University to see a well known ent who treats the country music stars voices. After seeing a local ent and now going to one in Cinti for over a year for botox shot to the vocal chords. I was diagnosed with sphaspomic dysphonia--vocal chord tightening.
Now I know the cause Prolia. I have a terrible time talking to people especially on the phone. They think I'm sick, deathly sick. I'm not. At my recent wellness visit-my dr told me I rank in the top 1% of women my agel--69. No other problems. I'm well and help my husband on the farm. I live with this voice problem every time I talk.
.

I developed vitiligo since having Prolia injections.

Had my first (and only) injection in January. This has been the worst 10 months I have ever had. March had severe muscle pain back of left knee, could not walk up stairs. Had to ask for help at airport when I could not walk very well. Went to Physio, did not help. Also began to have severe pain and numbness in my hands and feet, especially at night. Then i developed a terrible rash on my lower legs and arms, could not scratch hard enough.
Dr. suggested a couple of ointments, then a prescription, nothing helped. Finally asked to get an appointment with Dermatologist. Another prescription which is helping but still skin is terrible. This is end of October and my shoulders, upper arms are so sore I have trouble sleeping. In Sept. had a prescription for anti-inflammatories for a terrible pain in my hip. Thought it might be a fracture, but it wasn't. Never again, thanks.

I have been on Prolia for approximately 2.5 years and have been diagnosed with External Root Resorption on 6 teeth. There was no evidence of this six months ago. I am unable to have my teeth pulled as the bone in my mouth is too brittle which means that I am unable to get implants at this point. My only option right now is to have a root canal done on each tooth and then it's the waiting game. I have not had a shot since February and will not be getting any further shots. My last bone density test showed a slight improvement. ehealthme.com has an interesting report regarding women 60+ who have taken this drug. I have had six different dentists who have reviewed my X-rays and each of them has indicated that they have never seen anything like it. I am not on any other medication and only take a multi-vitamin and Calcium with D. I also had a fainting spell in January, two cracked ribs and bruised head, that was finally diagnosed as dehydration which is also a side effect. I too have notified FDA and Amgen the manufacturer. If anyone knows of a class action suit or lawyer who is taking this on, please post so those of us who are victims can get some help! Thanks and good luck to all.

I have had my second shot and have a very scary pain in my thigh bone. I just had an mri for my back pain. After the first shot, I complained to my internist that I was bent over and felt I couldn't straighten up. This happened after the second shot as well, but passed. Now my hip and spine are too painful. I also broke out. A lot of the symptoms listed are mine as well. How long does this stay in my system? I will not be taking another shot and will inform the doctor who prescribed it.

I have been getting Prolia injections 2x's a year for 3 years. I too, have been at a loss why I feel miserable with fatigue, pain, and flu like symptoms continually. Now that I know what has caused this misery, how do I rid myself of the Prolia medication? My last injection was May 2017.

I had one Prolia injection in Oct 1916. Two weeks later I developed pain and weakness in my back and legs. I am an extremely healthy Eighty year old woman. I do not take other medication except OTC vitamins,calcium and condrotin. I did not take further injections despite my physicians telling me my pain had no connection to the drug. The pain has concentrated in my right leg. I have had numerous tests for blood clots, and fracture but nothing was found to be causing the pain. I have pain in my legs at night when I am lying down. I go to the gym daily but can only manage 30 minutes on the rowing machine. I used to walk on the treadmill but my right leg feels like it wants to collapse. This is a seriously evil drug?

I had a Prolia shot on March 21st 2017. Since then, I have had a root canal, 4 teeth pulled, bone graft and oral surgery to try and correct the problem, including an implant that had to be removed. The pain is horrible for the past 5 months and am now trying to recover from the oral surgery. My dentist has stated he is sure the problem is caused by the Prolia shot.

Thank You

I took the Prolia Shot 2-19-2016. I went from a healthy woman who had just had a physical and the Doctor found nothing wrong with me , to a totally different person. I have had all the side affects you can have, now facing loosing all my bottom teeth, all the bone is almost gone want be able to wear bottom denture, Dentist afraid to pull the teeth , afraid the bone and gum want heal because of the Prolia Shot. Had two root cancels in less then 6 months, sores in my mouth lips, pain in Hips , Arms,legs,Shoulders, Blanche off to the point I could fall at any time.Fell once injured leg had to go to Wound Clinic 6 months or more.There r more side affects I suffered, But I will never take another Prolia Shot . The Side affects are still affecting my body.

I had my first Prolia injection 6 moths ago. My husband has had it for years and suggested it to me. My hair fell out. My muscles were in pain. My back pain increases significantly (always had a bit of discomfort) When I stopped after the first 6 months my withdrawal symptom resulted in severe foot pain, like planta faciitis for about 10 days long but my hair loss stopped IMMIDIATLY I will NEVER take another one. I take a low dosage Magnesium and rather take the risk of the unlikely event to break a bone.
This is from Australia.

My husband Steve was getting the Prolia shot for his osteoporosis. He started having a lot of problems with his teeth and when he went to an oral surgeon he told him to stop getting the shots immediately. Bad part, he had had one just the week before. In January of this year (2017) he had a full mouth exray and you can see where the bone had deteriorated on one side and was starting to do the same on the other. Since then, my husband has passed away due to a heart attack, so I am warning people against getting the Prolia Shot.

I am now 77. Horrific side effects began after my second shot March 2015 inc severe debilitating bone pain throughout my entire body. Unable to walk or do simple personal tasks I was an invalid for over a year in constant pain. A walker didn't help as my arms would not work. After blacking out I was in the hospital. My new doc said there was 88% inflammation raging through my body and I was headed for a stroke or heart attack when she started me on a high dosage med program which I feel saved my life. It's been over 2 years since the onset of this Prolia nightmare. I am still under my doctor's care, continue taking meds, but am getting my life back. The Prolia may or may not still be in my system, however the damage it leaves behind is life changing.

i have had 3 shots and have had shoulder pain, back pain, and hair loss,

My doctor suggested taking prolia when I was diagnosed with osteoporosis. I bought the drug and it had two sheets of side effects with it. I then looked up prolia and found all of your comments on this drug. Needless to say, I WILL NOT be taking this poisen!!! I can not believe those idiots even allowed this drug on the market!!

The side effects I am suffering from started with my first Prolia injection for osteoporosis in men which I did not recognize until my 5th injection on May 5, 2017

?> Loss of top four front teeth because they became loose
?>Loss of hair over the last two year s
?> Increased Cholesterol level

Since my last Prolia Shot on May 5, 2017 I started suffering these side effects within two days after the shot.

?> Unbearable pain in my right shoulder and arm
?> My cholesterol level went up since starting Prolia
?> I have constant back pain
?> I have the urge to urinate like six to ten times per day
?> Loss of appetite, I do not feel like eating
?> Loss of strength I cannot even pick up an empty cooler

I to wish to join any CLASS ACTION LAWSUIT – Prolia should be banned from the Marketplace

I tried Fosamax which caused me incredible pain so the doctor switched me to Prolia. My mistake.

Posted May 15, 2017

I have been getting Prolia shots for about 4 years. At Christmas time 2015 I started having trouble opening my mouth. My left jaw hurt so bad I couldn't get through a day without eating pain pills like crazy. I say an advertisement from an attorney's office saying if you've taken prolia and have jaw problems call them. I never called but when my next shot was due I asked my doctor. He said not to worry but he postponed my injection for a year. Last month was the end of that year so I called. Now he is going to wait 3 years. I had to get an appointment anyway because I was having terrible pain in my hips. He ordered an MRI and I just got the News that I have Avascular Necrosis and the femur bone in my right hip has collapsed and my left hip has damage also but has not collapsed yet. I see a surgeon next week. I looked on google and found an article that points this all back to prolia. It causes a decrease in blood going to the joints and the bone dies. Needless to say I am horrified. I went from an active life to struggling to get to the next room. I am the soul caregiver for my disabled son and now i'm facing maybe multiple surgeries. I just pray that the pain I am now feeling in my knees is just from my walking different as the article said it also effects the knees, shoulders, and ankles.

September 30th of 2015 my husband was given 1 of 2 shots of Xgeva (Prolia) for bone deterioration due to prostate cancer.
My husband was told that the side effects were minimal mainly tiredness.
Less than 2 weeks later one side of his face became numb. I called the doctor's office the nurse told me that the doctor said not to worry his body was getting use to the medication. a few days later he was so week that he needed assistance getting out of bed.
Then no appetite. needed a walker to go to the bathroom. Called the doctor again I was told we have to give it time. He was scheduled to go back to the office for another shot Oct. 30th 2015
This time my son wheeled him in, in a wheel chair.
The Physicians Assistant ran out of the room and called the doctor, came back and said "No more shots" and took a series
of blood tests. That night I got an emergency call from the Assistant stating my husband had to go into the hospital because his potassium was extremely high, another blood test showed that his sodium was extremely high. I contacted my husbands primary care doctor we put him in a hospital thinking that once the potassium sodium levels were stabilized he would be O.K and we could contact an Orthopedic Oncologist. The length of time he was in the hospital was 21 days.
My husband passed away Dec.3rd 2015 Less than 8 weeks from the time he received the shot
Doing research later, we found out that in people that already have cancer Prolia produces at first, a Cancer flare. Yet the doctor told us that Xgeva (Prolia) was having success building bone in Cancer patients.
We believe my husband had more years left to his life and Xgeva (prolia) cut them short.

Had prolia shot in November 2016 and body aches began about two weeks later. They persist still. Cannot sleep because of pain. Started in lower extremities and now in arms and shoulders. Taking ibuprofen double dose every 6 hours. Will not be getting another shot!!! This horrible drug should be taken off the market!!

Without going into great detail. I need to ask how does Prolia poison leave the body once the 6 months is over ? Thank you

My long list of side effects started approximately 2 months after receiving my 7th Prolia shot. I experienced extreme fatigue, fever, and could not sit comfortably for about 6 weeks. I could not lift my arms above my head and could barely dress myself. I was diagnosed with frozen shoulder. It has been almost 11 months since my last Prolia shot and the side effects I mentioned above are better. I still have pain in my hips, groin, and shoulders. I have trouble climbing stairs and I feel "stuck" after sitting even for a short amount of time. I cannot stoop down to pick something up due to the back of my legs being extremely tight. My husband and I have noticed a difference in my gait when I walk due to the hip pain and I've had to stop walking on my treadmill because walking aggravates my hips. I occasionally experience dizziness when I roll over at night. This last shot has pretty much stopped me in my tracks for almost a year now. It will definitely be my last Prolia shot.

My mom had one injection 2/10/2017 and her life has been hell. My mom will cry and say all this because of a shot. My mom who has always been a fighter, made the comment that living is not worth it any more since this shot. Extreme pain to the ER ended up getting an injection in her back for the pain, plus an increase in her morphine. Increase pain in shoulders, and hips. Fevers on and off. Now fluid on her lungs. Muscle cramps. Extreme fatigue to where she can not get out of bed. Bladder issues, diarrhea, poor appetite,and the list goes on. The sad thing is it has been a month and symptoms keep adding to the list. PLEASE WARN OTHERS NOT TO TAKE

I received two injections of Prolia in 2016. I have been extremely ill since then. I have experienced all of the mentioned symptoms in these blogs. I went through a series of CT scans and still have no answers. Doc says not related to Prolia. I wanted to ask him who gave him his injection. I am concerned the medical community is afraid of lawsuits so no agreement from them to date. The aches and pains never go away. I now have liver problems with no prior difficulties. Developed pancreatitis. I do not consume alcohol so go figure. This is extremely dangerous chemical injection. Take your chances with osteoporosis rather than this quick fix which does not exist. Walking, taking calcium vitamin D, sunshine, good diet is an easier and healthier way to go. Just call me "regretful"

I have had a series of 2 shots of Prolia. Third shot is due April 6, 2017. I will not be taking the 3rd shot. Within the past year I lost 2 teeth and another one is loose. I've lost hair and have peripheral neuropathy in my left foot. The way things are playing out I would rather have broken bones than be bald, toothless and limping.

I was given a prolia shot in my left arm 9 months ago after a bone scan showed osteopenia. Within a few weeks I had terrible pain in my hips and thighs. Then I began to have recurrent bladder pain feeling the constant need to urinate and pain in my back. There urine tests showed I have blood in my urine. And after 3 antiobiotics the infection is no better. I also began having deep pain in my left arm 2 months around my rotator cuff. I am seeing and orthopedic dr and physical therapist. The x ray and MRI show I now have a frozen shoulder and will be having manipulation surgery this month. I am convinced all of my painful disabling illness has been caused by the Prolia. I am devastated and so scared.

I have been getting Prolia shots for about two years now. I have severe bone and joint pain. My right arm hurts so bad I can barely use it sometimes.My teeth ache all over, and I have a blister-like sore on my ear that will not go away. I will not take the shots anymore and I cant take the pills either. I don't know what to do.

I had my second Prolia shot in March 2015 after which the side effects began. After almost 2 years of severe bone and muscle pain, and numerous other miseries too numerous to list, I can now walk somewhat normally and do most things for myself. The improvement is due to my good Rheumatologist who found that my body was inflamed and immediately started me on a regimen of meds that I believe literally saved my life. Before Prolia I was an active 75 year old that exercised and walked daily. Prolia put my life on HOLD, but I am thankful that I am heading toward total normality. Jan 2017

I had my second Prolia injection July 2016, a week later blood in my urine, which I've never ever had before. Massive UTIs continually for months. Antibiotics didn't seem to work. Ultra sounds on kidneys and bladder, a systcoscopy by a ulorologist. By September I had the worst chest infection, couldn't breath, doctor thought I was heading for pneumonia. The aches and pains in my hips, legs and arms are something I had never experiences before. I am about to head off to the doctor again for my newest symptoms, fever, chills, sore neck, arms and night sweats with extreme tiredness and no appetite, and that's just not me. Worst is the fact no one told me about side effects and since reading about it all and mentioning it to the doctor and urologist, they both think it's a coincidence. WTF.

I was very ill for nearly two years during which I had three Prolia shots. I have NEVER had a reaction to a medication before and never dreamed it was from the shot. Some meds have not worked for my osteoporosis so went to the next new one to try. I had my last shot in June 2015 and ended up in emergency on a trip two days later with swollen lips. Had at least a year of upper respiratory infections that did not respond to anything, terrible coughing that eventually caused a horse voice that still is there - not as bad as before, but if I get a cold or anything I can hardly be understood. Then I started getting weak and shakey, broke out in continuous hives all over, ended up in emergency several times, once one side of my tongue swelled up, eye swelled up, lip swelled. I was tested for allergies (negative), Lupus (negative), thyroid (negative), damage to throat (negative) to name a few. Could not keep my blood pressure under control so kept trying other meds, have had two teeth pulled and others filled. My husband and I were watching an ad for Prolia on TV and when they listed the possible side effects it fit mine to a T. I called my Dr. immediately and she said that was a real possibility so since I was due for another shot we cancelled it. I then asked to be taken off ALL the meds they had me on including Prednisone and just deal with the blood pressure and pulse problems. She set up a schedule of withdrawal and after each one if the hives didn't come back we proceeded to the next med. After a year + I have no recurrence of the hives (large water filled blisters) but still have periods of shakiness and itching, hoarse throat and tooth problems. I hope they take this drug off the market. Right now I am only taking Calcium/Vit.D, low dose aspirin and Losarten/HCTZ for my blood pressure.

I have taken three Prolia shots. Due for a 4th in December, 2016. I will not be taking it because of all the problems I have had since starting them. My doctor said none of those systems are from Prolia. I find it hard to believe that all of a sudden upon taking the shots, I developed severe symptoms that I never had before. Symptoms include, leg and foot cramps at night, aching all over especially legs and hip,extreme skin change, skin itching, 2 UTI infections that I haven't had in years, diarrhea, seems like blood with bowel movement, have had colonoscopy within year, no problem,can'the seem to excrete a good bowel movement, tired, low energy level. Totally all came on all of a sudden. Had a MRI on my back which shows some scoliosis. Doctor said back is in bad shape. I was going to therapy for sciatic pain down my leg. I due not have that anymore. None of the over the counter pain relievers help. Have gotten prescriptions from dOctober for arthritisale, which doctor said I have and they don't help either. In closing, I believe this all is due to the Prolia shot. I am going to doctor today because I can't sleep because of my aching body. I am 76 and always had excellent health.

I do not know if Prolia is the cause of my problems or not. Within about 2 weeks after the 1st and 2nd, I noticed my skin was peeling on arms and legs. Nurse said absolutely not, she never heard of such a thing. (tho it IS listed as a side effect) And in the past year and half (had 2 shots, 3rd due in December) I am in constant pain in my left hip, groin down leg into ankle and foot on left side. First doc said it was sciatica (my thought too), then said no, it is sacroilliac (sp.?), now saying it is pinched nerve from L4 to6 surgery 2 years ago. Had three injections in spine and butt for the pain - relief for about 2 days. I am now unable to get out of the house much, now need a rollator even to get around in my tiny apartment (am 79 years old) am awakened during the night and am up for hours, by the pain, and am truly in agony ALL day. Couple of times I have talked one of my docs into a few Percocet or Tylenol with Codeine. So every now and then I have a couple of hours of 'normal'. I keep saying a little relief feels like I died and went to Heaven!!! It is brutally painful all day and night and I am going downhill for the past year. Now that I have read all the other comments, I am wondering if all my problem is from the Prolia.

My 80 year old mother with Rheumatoid Arthritis received a Prolia injection on May 19, 2016. Within two days she was suffering with what doctors thought was an upper respiratory infection or allergies. They put her on steroid inhalers and followed up two days later. Wheezing was just as bad and pain in chest had begun. Doctor took an x-ray ruled out pleurisy and gave her an antibiotic. Pain in chest moved into shoulders and within a six week period she was hospitalized twice and in the ER seven times. After the first week the Rheumatologist who suggested the Prolia injection felt she was having a reaction to the drug. All blood tests, x-rays, CT scans, and doctor visits have not been able to find a cause for the extreme pain in her bones with the most severe being in the hips. She went from an active senior to bed ridden using a bedside commode. She has gone from NORCO every 4 hours to Percoset. It still does not control the pain. Her blood work now indicates some type of bone marrow issue and she is having an MRI and bone marrow biopsy. The same test results were normal within 30 days prior to receiving the prolia injection as was her calcium and iron levels. Her blood protein which is regularly monitored has now more than tripled. Doctor performed tests for lymphoma and she is negative. Her doctor thinks it may be a spike due to the prolia shot and could just go back to levels prior to the shot over time. Although she suffers with the effects of high protein levels in her blood. Personally as her daughter I am tired of Doctors who keep asking me if she has fallen and that is why she has so much pain. I'm sick of Pharmacist who give me grief with her prescriptions because of the regulations and her need to increase due to pain levels escalating. I am tired of doctors who will give her a pain injection in the ER room after a 6 hour wait and send her home without any new treatments for her pain. I am sick of her GP who knows how much pain she is in and still insists she run out of medication because he needs to see her. Which then sends us back to the ER and the cycle continues. She just wants to die and cry's about why she ever took the shot. Every doctor doubts that all of this could be caused by the prolia shot but concur that it is the only possible reason after test after test comes back negative. Her Rheumatologist is "investigating" if there is a negative interaction between Embrel and Prolia. I would love to be included in any suit against this company and nobody should take this drug ever.

In 2013 I received my only Prolia injection 1 year after being allergic to other bone strengthening drug. Within 1 hour of shot I had severe nausea and diarrhea. Within 3 hours, fever , chills, flu like symptoms lasting 3 weeks. Since 1 month of shot I have not been able to seep in a bed due to severe hip bone pain. Have slept in a recliner for 3 years. My jaw bones hurt constantly. Severe pain in feet, knees. I have to take calcium because my blood calcium levels fell severely low after shot.
I was 57 when I got shot and I have felt 120 since. I have had spots come on lungs since.
No one talked to me about side effects.
I beg you to think long and hard before ever taking Prolia.I would do anything if I could undo this. I can't enjoy my life , grandchildren since Prolia resulting in depression. My grandchildren were my life.
This should be investigated to see if proper testing and FDA laws were followed.
If I was offered a million dollars to take again, I would NOT!

My situation is pretty similar to Sue's posted 8/25/15. In early 2015 I was told that the results of my bone density test was very alarming & was referred to an endocrinologist. His tests confirmed the first diagnosis & suggested prolia. He said that there were very few side affects & never mentioned anything about possible major jaw problems. I researched the side affects of the drug before I agreed to the shot. At the time, the only side affects that were mentioned on their site was possible muscle pain, diarrhea, dizziness & a sore jaw bone. Since none of this seemed too serious, I agreed to the shot on 6/15/15. Within 2 weeks I woke up so dizzy that I was spinning which lasted for a couple of days after which I remained simply dizzy for a couple more weeks. On 10/18/15 I had diarrhea so bad for 2 1/2 weeks that I couldn't even leave the house. The worst side affect, however, is when my bottom right teeth were bothering me. My dentist said that I needed 2 root canals which we completed. The problem was that they didn't heal like all other procedures I've had done in the past. She finally asked me if I'd taken anything for bone density which of course I had. She was very concerned & referred me to a DMD who said I had osteonecrosis which has no cure. In the end, I will lose my bottom teeth & possibly need surgery for my jaw. More stringent warnings are now included in this drugs' warnings but they weren't when I originally researched them. I reported these side affects to the FDA & personally think it should be taken off the market & is worthy of a lawsuit.

I had a Prolia injection in 2014. It was the worst drug I have ever taken. I was sick in bed for a year and a half and still do not feel myself. I couldn't breathe, pain in back, legs and arms was terrible. Hospitalized 3 times, emergency room 3 different times, sooo many doctors visits, lung biopsy and every test imaginable...couldn't find the problem. I know the problem...PROLIA!!! It all started within hours of this injection. I wish I had time now to tell all of you everything that went wrong but I don't. I wouldn't recommend this drug to anyone. I have notified the FDA and made a monthly call to the AMGEN CO. with no help from either. I can't get anyone to help me.

I posted on April 26, 2016 regarding my reaction to the Prolia injection. Since that post, I have had to get another steroid shot the end of March and again on April 27th along with an antibiotic to try and clear up the rash on my legs which I still have as of today. I would definitely like to be included in a class action suit against the manufacturers of Prolia.

Took Prolia injection 4 weeks ago. Worse overall pain in my entire body. Anyone considering taking this "poisonous drug" be better off in taking a real poison if you want to ruin the rest of your life. PLEASE BE EXTREMELY CAREFUL, AS PROLIA MIGHT ACTUALLY KILL YOU OR AT LEAST PERMANENTLY DISABLE YOU. If anyone is considering a class action lawsuit, please include me

Got Prolia shot Jan.20 2016. Within 6 hrs. had awful pain in my hips,lower back and neck. Have lost tons of hair, sores all over my legs,arms and ulcers on my tongue so bad I couldn't eat. Have numb toes and dizziness every time I stand and blurred vision.It's almost 6 months now and side effects are not getting better. Prolia should be taken off the market! Pure poison.

I had my first & no doubt, last Prolia injection 4 wks ago.
No immediate teaction but within about 5 hrs that night, pain started in my toes and fingers. It was excrutiating to walk. By the next day, I was in pain in my bones and joints and didn't want to walk at all; huge ordeal to get to restroom. Pain continued down shins, nausea and vomiting, severe GI distress for 3 wks with severe GI issues; even my voice has changed.
Pain has started to decline over past 2-3 days.
I have broken a total of 5 bones, my shoulder was a catastrophic break, healed wrong and left me with limited range of motion. Due to thin bone density, my ortho surgeon wouldnt consider rebreakung and resetting after 6 months of physical therapy.
Many years ago, I had Actonel prescribed & of course, it tapped out. Still after all of this hell, I doubt I will take the second injection in November. I am an RN, have Systemic Lupus & take steroids which thinned my bones. I dont know how this drug made it out of trials. Poisonous indeed.

Have posted earlier but am still having problems since FIRST AND LAST Prolia shot in September 2014.

My toes are numb, my hair is falling out by the brush load, have itch, depression, balance problems, and most concerningly problems with my kidneys.

Initially diagnosed with UTI which anti-biotics fixed, but now UTI symptoms that show no infection. Pain in my flanks and lower back and am having more blood work, ultrasound of kidneys and CT scan on my stomach. Also standard X-Ray of my back. I await the test results.

My doctor/s still say not Prolia related, and I understand that correlation does not prove cause, but I have had a cascading set of horrible symptoms that occurred DIRECTLY FOLLOWING my first shot, so am definitely not convinced that Prolia is not the cause.

I was a happy and active older woman until receiving the poison Prolia and can hardly drag myself out of bed.

I warn all people I know about considering EVER taking this drug. It has really messed with my life.

My love and best wishes to all who are going through this nightmare.

I get severe breathing problems since starting prolia January 2015. All heart and stress tests are negative. Does anyone else have these symptoms?

I received my Prolia shot on January 8, 2016 after much discussion about the side effects. Was assured it was totally fine. On January 14, 2016, I started having chest pains and couldn't swallow. Had burning when I urinated. Went to Urgent Care on January 16, 2016 for urine test to see if I had UTI. Came back negative. Broke out in a rash on my legs. Called doctor on January 19, 2016 to get a steroid pack because my eyes were swollen shut. Started throwing up the steroids. Stayed home from work on January 20, 2016 and slept all day. Had no energy and slept for the next four days. Lost 7 lbs. Went to work on January 26th and got really dizzy. Tried to drive home. Pulled off interstate. Passed out after I got home and had to be taken to ER by ambulance. Blood pressure got up to 203/106. Stayed in ER for 3 hours. Went to my doctor January 27th who changed my blood pressure medicine to stronger dosage and then it had to be doubled. Stayed home from work for the next week. Had to go for another steroid shot on February 27th because I broke out in another rash and my eyes were swollen shut. March 29th, blood pressure spiked to 180/100. Had to take another bp medicine to get it to come down. Stayed home from work on March 30th. Legs continued to stay broken out in firey red rash. Using Topical Antibiotic Solution prescribed by my Dermatologist. Told my doctor that I would never take another Prolia shot and not sure if my rash will ever go away on my legs. Have told everyone I know to not take the shot.

I thoroughly read all the literature on the side effect of Prolia. I asked five doctors about the side effect of Prolia. All of them reasured me that in their experience the side effects were minimal. I received the Prolia Injection on July 26th 2016. Immediately I became dizzy and had to be assisted out of the room. My friend assisted me home. The next day I suffered a pain in my chest and was advised to go to the emergency room as I was having a hard attack.. I was assured that there was nothing wrong with my heart. I fainted and given all the tests, cardiolology, neurology, and middle ear exam. By now, I was dizzy all the time, could not walk a straight line, unable to stand without being dizzy. and verdugo sympthoms.
I was informed I would never recover and the Prolia shot effect my electrolytes.

This has continued, despite physical therapy. I have to live in an assisted living home as I can not live alone because I am a fall risk.

I had 3 injections over the course of 18 months. After the 2nd one, I'd wanted to stop because of the INTENSE pain in my femurs, hips and lower back. The bone density report had improved so much, the dr. talked me into the 3d injection. I was in unrelenting pain, and I do not think it was a coincidence that there was suddenly a sharp spike in my cholestoral levels. Now, come to find out, the "calcium" scoring test shows me off the chart of good health, and a lumbar X-ray shows a vascular calcification. I so regret having done this therapy and feel it should be removed.

I had the Prolia shot Nov. 12. Around Nov. 16, I began to get
sores in my mouth, my tongue began to began to get numb &
the tip of the tongue had small cuts in it. Then I developed an extremely dry mouth. My dentist said I was developing no
saliva.
Dec. 16 I had a UTI and went through 5 doses of antibiotics.
I was in severe pain in my right lower abdomen and lower right side of back from that date until present. The end of Feb. my
doctor sent me to a gyro urologist because blood was in the
my urine 3 times. The new doctor said I had interstitial cystitis,
but my CT was clear, my cystoscope was clear, and after 5
bladder installations, I was no better. On day of 6 th visit, I told them that. I had run a fever all weekend and the pain was mire
intense. They said I had a UTI! Gave me a antibiotic, but after
a week, they called to say according to the culture, I needed
to take another antibiotic! I went to see my family doctor
who believes. somehow I gave a very resistent UTI. And, after
reading about Prolia said that could very well be the case. This has been a nightmare!!

I had a Prolia injection August of 2015. The next morning I woke up with a mouth full of ulcers on my tongue, roof of mouth, & gum line. I immediately went to an oral surgeon. As soon as possible he did several biopsies & the results came back as a bacterial infection.(Immune system) Which is a prolia side effect. Within the next 3 days my hips, groin, I thighs were in horrible pain. I had muscle spasms that kept me awake @ night & still does to this day. In a couple of weeks my hair started falling out. All of the above are side effects of prolia. I am now past 7 months & continue to have all of the original effects of poison prolia. Needless to say I have made many visits to the Dr. to get something for pain. These was senseless trips. As I was in absolutely " NO pain" prior to the shot. On the Nat. Cancer Institutes site, it states that prolia is a cancer drug used to treat prostate & breast cancer. I do not have cancer & am very angry over being given this drug for osteoporosis. I have contacted the FDA twice & the Mnfr. Amgen .(Maker of prolia) My next venture is to contact both of my insurance companies & ask that they discontinue approval of this drug for treatment of osteoporosis & save thousands
of women from all the needless pain & suffering this poison
has created.

I had my fist Prolia shot June 2015, I had a hard time deciding if I should take the shot so I spoke with the nurse in length before she gave me the shot and she told me that she had been giving the Prolia shot since it came out and had never had a reaction complaint from any of the patients so I took the shot. here are a list of the reactions I had and reported to my Dr. he took me off Prolia and ran blood test that he said came back normal but he even told me not to take any kind of supplements.
Pain in extremities, bone pain, rash in hair back of head, loose front bottom teeth that will probably fall out, vertigo, double vision that lasted about three weeks, anger issues almost violent at times, and now I have a very small cluster in my breast that showed up on an ultrasound that I have to wait six months to see if it grows or calcifies I was told not to worry that it doesn't look like anything serious but I am worried because I just read that new malignancies related to the breast have been reported while on Prolia.

Received Prolia shot September 2014. Crushing rib pain, hair loss, bruising, rash, bladder infection and now symptoms that mirror bladder infection but tests show no infection. Unusual bleeding in that I had a blood test and when syringe was removed blood flowed from the site. I have had many blood tests in the past and have never had this occur. I hate this drug and would not recommend it to anyone. I'm still suffering the bladder problems.

After a Prolia injection in late October 2015, my hair started falling out. I've had only minor pain issues but now feel horribly depressed due to the hair issue. But then I see depression is also a possible side effect. I am sorry I did not do my own research on this drug before agreeing to receive it. I will not get another shot. Ever!

I took my first and only shot of Prolia in June, 2015. Almost immediately my leg up in groin area started hurting. I went to Orthopedic Doctor. He asked if I had been in accident or anything. I of course told him no, but I had taken a shot for Osteoperosis on the almost instance of another doctor. The medicine was Prolia, and he said "oh you shouldn't have taken that"! He told me about the unusual thigh bone fractures and told me that he (and the industry) have already been seeing this bad side effect! He did xrays, etc and said there was activity on the bone. Put me on a walked and told me to see him in a month unless the pain was worse. Well, it did get worse so I went back. More xrays, etc, then finally on one visit he said he needed an MRIl. So I went and had one, a few days later he called me to tell me that it was fractured and that I need surgery ! Has anyone had this surgery?

I had my first and only shot of Prolia in late August 2015. About 5 days later my face turned fire red and eyes swollen shut. Then my right hip which was replaced in May and was healed started butting when I walked. Then I started with serious diarrhea and weight loss. I am now on medication for depression and do not want to get out of bed. I've been to my doctor and he prescribed a topical ointment for the skin on mr face legs and arms. I called the people at Prolia and after telling this man all of my problems he said "How do you know Prolia was the cause". My Doctor has filed a complaint with the FDA. How long does this last and is there an antidote?

My mother received Prolia shot on Sept 23 2015. A few days later woke up with tightening of the throat, tongue and face swelling. Was called by a dr to go to the nearest trauma center due to a decrease in kidney function and liver at crisis state. She had CT Scan due to complaints of a tight band feeling around back of head and a cardio gram and passed those. Went home and was called by another dr to come in for blood work. A nurse then called and told my mother she should have never gotten that shot. The blood work came back as hemoglobin down to 7, kidney function dropping and liver crisis state. She was admitted into hosp and was started on a gamet of testing. On day 2 lungs started to fill with fluid, IV shut off and given IV lasix. Over the course of her 8 day hosp visit was given 2 units of iron still the tests came back with no diagnosis. Having consulted with drs on a daily basis suggesting Prolia may be the culpret they turned a blind eye. My mother now resting with no diagnosis but was told at her follow up appt she was to never get that shot again. I have gotten on the Prolia website and did my own research and have have found she has multiple side effects like those associated with Prolia.

I had the Prolia injection in June of this year into my right arm. Few days later my arm and shoulder hurt so bad it made me sick to my stomach. I called the doctor that gave it and she said oh it will go away take some advil and other patents complained of this. Never went away as of today. I went last week and had a MRI. Results I now have what is called Frozen Shoulder. This is a result of the Prolia Injection. I am so upset over the fact that the Doctor that gave me the injection said little to no side affects. She also stated that Prolia is not what has caused my issues to my shoulder and arm.

The comment by Janet is the first I have read that seems to pertain somewhat to my situation. In May of 2014 I received a Prolia injection. At that point I had no other physical problems but Osteoporosis. Six weeks later I saw my dentist for what I thought was a toothache. She suspected I had osteonecrosis of my lower jaw and referred me to an oral surgeon. I also had a root canal above the dead bone area that I now think was probably unnecessary. Since then I have had monthly visits with the oral surgeon as he observes the affected area. My most recent visit after a six month period showed that the size of the dead bone had increased. So my oral surgeon visits will return to every 3 months. There is no fix for it. Surgery would only make it worse. I am in a holding pattern and am just waiting for the dead bone to release and fall out, as I was told would probably happen, and hoping that it does not again increase in size. I came to this site to search for others with osteonecrosis that had not had cancer treatments but had received Prolia injections.

I had an injection of Prolia and 2 months later I started a dental implant in the lower left jaw. I also had an implant in the lower right that became loose. After the surgery I began to have severe pain in both jaw and was on narcotic pain meds for about 6 weeks. Almost a year later I still have discomfort, have significant bone loss, and the surgeon (not the original, who is no longer with the practice) is being very cautious about doing anything but waiting and examining the sites every 3 months. I did inform the original surgeon that I had taken the Prolia injection but he seemed unconcerned. The new surgeon seemed unfamiar with Prolia but is well aware now.

Received my Prolia shot in Oct/Nov 2014. I immediately started to have pain in my hip and groin area. Thought it would go away, took pain meds and still had pain. Rec'd shots in my back, still no relief. Finally tried a chiropractor and was informed that what I have is one of the side affects from the drug. Is there anything that I can take to help this problem. Thank you