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In addition to reporting liver problems, female patients who might be given a drug containing sodium valproate should inform their doctor if they are pregnant or planning to become pregnant.
Patients might also want to ensure that their doctors are monitoring their liver and pancreatic functions while on sodium valproate. If patients are suffering from markedly reduced appetite, yellowing of the skin, severe abdominal pain and nausea, it may be a symptom of a liver or pancreatic problem.
Depakote side effects include nausea, gastric irritation, weight gain and increased ammonia in the bloodstream. Also, sodium valproate can lead to an increased chance of Depakote birth defects, such as spinal bifida.