True Story: I saw a comment from a reader here at LawyersandSettlements.com who had gone to the doctor to get some help for his acne. While there, the doctor noticed that this guy’s hair was starting to thin. Long story short, the guy walked out of the doctor’s office with a prescription for Propecia. He now claims he suffers sexual side effects (like erectile dysfunction and impotence). Oh, and btw, he still had his acne.
It got me thinking…
I’m not a glass-half-empty type, but it’s easy to see how, with prescription drugs, one can envision a worst-case-scenario downward spiral of things—especially given the potential side effects with some drugs that are on the market.
So then I started thinking, what if…
What if a guy goes to the doctor for acne. What could happen based on which drugs he’s been prescribed and what the side effects of those drugs could be? The graphic above depicts “The Snake Pit” (classic movie if you haven’t seen it) version of taking prescription upon prescription. A modern day Dante’s “Inferno”. Only in this little vignette, no one emerges from hell in their attempt to mitigate (via new prescriptions) the snowball effect of increasingly negative side effects.
Here’s how this plays out.
(Note, yes, it’s hypothetical, assumes various doctors/specialists involved, and yes, assumes worst case and/or rare scenarios…but still, it could happen. And before you get on me for Accutane being off the market, the drug isotretinoin is still alive and kicking…)
A guy goes to the doctor for acne. He’s given Accutane (isotretinoin). A possible side effect of Accutane is Inflammatory Bowel Disease (IBD). To treat the IBD, he’s given Cipro (antibiotic) and Prednisone (corticosteroid). Cipro has been linked to tendon rupture. Reported, though rare, side effects of Prednisone can include high blood pressure and osteoporosis. Assuming his luck is nil, he experiences these side effects and is given Lisinopril (ACE inhibitor) to combat the high blood pressure, and Fosamax to help combat the osteoporosis.
As we know, Lisinopril has been linked to liver damage (or worse, liver failure). And Fosamax has been under fire for femur fractures. Which, outside of pain meds—which have their own set of side effects—requires another form of medical intervention (surgery). So we come to a “STOP” on that path.
But between the Accutane and the Lisinopril, he begins to experience some hair loss as well—a rare side effect of both drugs, and he’s Mr. Unlucky. So next up, Propecia. Propecia side effects include sexual dyfunction. And he finds himself having some “issues” on the love-making front. Well, there’s a drug for that—Viagra! But let’s face it, between hair loss, sexual dysfunction, a broken thigh bone, a ruptured tendon, high blood pressure and some bowel problems, is it any wonder this guy’s now depressed? So, it’s time for some SSRI’s—like Prozac. And Prozac’s been linked to suicidal behavior.
And, with that, I guess it’s another “STOP”.
Floxed. Sounds so innocuous—or at least like some casually tossed remark about the previous night’s escapades—as in “yeah, I got really floxed up last night”. But to the victims who have come to add the word “floxed” to their everyday vocabulary—and who are a part of the been-floxed wall of photos (aka, Wall of Pain, see pic) on the Facebook page, Fibroquins Levaquin—”floxed” is insiders’ jargon for having gone through serious adverse side effects from taking a fluoroquinolone drug. Getting floxed, therefore, isn’t like picking up a mayor badge over at foursquare—it’s more like a badge of camaraderie that ties fluoroquinolone victims together—better not to have it.
Fluoroquinolones are part of a class of antibiotic drugs—i.e., drugs typically prescribed to treat bacterial infections such as urinary tract infections (UTI), ear infections, bronchitis, inflammation of the prostate, typhoid fever, salmonella, chlamydia, pneumonia, etc…so chances are, either you or someone you know has been prescribed a fluoroquinolone at some point. Fluoroquinolones are more commonly known by some of the brand names that get prescribed: Levaquin, Cipro, Floxin, Avelox, Noroxin, Tequin.
So what is getting floxed all about? How do you know if you’ve been floxed?
In 2008, the FDA added a black box warning to Levaquin, Cipro, Avelox and all fluoroquinolone-class drugs. The black box warning is for risk of tendon rupture and tendinitis—the FDA alert (7/8/2008) stated:
Fluoroquinolones are associated with an increased risk of tendinitis and tendon rupture. This risk is further increased in those over age 60, in kidney, heart, and lung transplant recipients, and with use of concomitant steroid therapy. Physicians should advise patients, at the first sign of tendon pain, swelling, or inflammation, to stop taking the fluoroquinolone, to avoid exercise and use of the affected area, and to promptly contact their doctor about changing to a non-fluoroquinolone antimicrobial drug.
The Levaquin stories we hear at LawyersandSettlements.com are real and heart-breaking—and for those who have been floxed, they are life-altering—and not in a good way. The victims who’ve started to band together on Facebook share their stories of lives shattered and forever changed: cane-assisted walking, wheelchairs, numbness, burning sensations, cramps and worse.
And those who’ve been floxed are angry—at the FDA, at their doctors, at the pharmaceutical companies. Sure, they can try to file a lawsuit against Levaquin or Cipro—that’s what I’d be doing—but doing so won’t bring back their lives. And as such, one can only wonder if getting floxed is really akin to getting fleeced.
According to many sufferers, the antibiotic drugs Levaquin, Cipro and Avelox are causing a lot of damage including tendon tears, ruptures and more.
I had the opportunity to interview John Fratti about his experience with Levaquin. As you can see on his youtube video, Fratti has become quite a grassroots activist—passionately voicing his concerns about the possible risks of taking fluoroquinolones, namely Levaquin, Cipro and Avelox (Fratti took Levaquin).
Of course, many lawsuits right now are focusing on Levaquin (distributed by Ortho-McNeil Pharmaceutical) and its association with tendon rupture—not all the effects Fratti talks about here.
However, the antibiotic has come under fire recently for some other adverse effects, including liver damage. The website drugs.com also states that, “in rare cases, Levaquin has caused convulsions and other nervous system disorders… restlessness and tremors to depression and hallucinations… nerve pain, burning or tingling sensations, numbness and/or weakness, or other changes in sense perception.” So maybe Fratti is onto something?
It is estimated that one in every ten people will take a fluoroquinolone antibiotic during the course of their lifetime, and chances are it would either be Cipro or Levaquin, the two big blockbuster drugs. Take this statistic, add the fact that the FDA says less than 10 percent of all drug side effects ever get reported to their agency, and throw in the equation that many US troops were given Cipro, chances are countless people have suffered tendon tears and ruptures from these drugs. And according to Cipro patients writing online, Cipro’s adverse events are not as rare as the drug manufacturer—Bayer—would have the public believe.
And let’s not forget the Anthrax scare in 2001—if you recall, the antidote to have on hand and the drug that became the media darling during that scare was none other than Cipro. Read the rest of this entry »
Attorney Mike Stratton points out that Bayer’s patent on Cipro will expire soon and Ortho-McNeil’s blockbuster Levaquin has been targeted for the majority of lawsuits against the flouroquinolones family, so it is likely that Bayer may soon push sales of its more quiet cousin Avelox—described by Stratton as “the elephant in the room”.
Flouroquinolone antibiotics are the most commonly prescribed class of antibiotics, yet many of them have been removed from the market due to their severe toxicity (e.g., Trovan, Tequin, Zagam, and Omniflox). Is it just a matter of time until Avelox is taken off the market or does Bayer have more control over its drugs than the FDA? (According to one website, the FDA gets about half of its funding for the review of drugs directly from the pharmaceutical industry in what is called prescription drug user fees.)
Although Avelox was slapped with a black box warning regarding tendon tears and ruptures, Bayer says that Avelox (and its close relative Cipro) are “effective and well tolerated” but try telling that to the many victims who have registered complaints on medical websites and their own personal blogs. This from one Avelox victim: “…yes, the potential for a ruptured tendon was mentioned in the [Avelox] box insert. But it was printed, like everything else was, in teeny tiny type. And of course, we never think WE are the people who will have the problems, do we?)”
Like that woman who suffered ankle tears, not everyone prescribed Avelox and suffering from tendon ruptures will make the connection between the drug and adverse events right away. After all, drug side effects actually reported to the FDA typically only involve about 1 percent to 10 percent of all problems experienced by users. However, there will likely be many Avelox lawsuits soon–just take a look at Levaquin.