The Research on Reglan

February 3rd, 2010. By janem

Sixteen years ago, the Health Research Group of Public Citizen published a report in its Worst Pills, Best Pills News regarding the heartburn drug Reglan and the link to tardive dyskinesia-often an incurable and irreversible disorder. But the FDA didn’t slap a black box warning on this treatment for heartburn until last February, 2009. Talk about closing the barn door after the horse has bolted…

When you consider how many people are prescribed Reglan–dispensed 6.5 million times in 2008–it’s mind-boggling that the FDA didn’t act sooner.

My friend suffers from tardive dyskinesia and it’s not a pretty sight. His eye is constantly twitching and he can barely control his jaw when he’s talking-like he’s grimacing all the time. Some people think he has Parkinson’s disease. Because of this disorder, he lost a job in retail and now works as a line cook in a chain restaurant-a job that doesn’t suit him.

My friend is 50. He doesn’t know how he got this disorder and neither does his doctor, but he does remember taking a med for heartburn years ago…

The FDA approved metoclopramide, the generic name, way back in June 1985. I wonder how many people have tardive dyskinesia and took Reglan years ago and haven’t connected the dots?

This is how Reglan works: it stimulates the muscles of the gastrointestinal tract including the muscles of the lower esophageal sphincter, stomach, and small intestine . That in turn stimulates more rapid emptying of the stomach as well as decreasing the reflux of stomach acid into the esophagus. Some patients, particularly those with diabetes, have nerve damage in the stomach and that causes delayed emptying of the stomach, resulting in heartburn and other symptoms.

I’d take heartburn over tardive dyskinesia any time. Or take another drug for heartburn!

Getting back to Public Citizen, I’m a big fan. When my doctor prescribes a new med, Worst Pills, Best Pills is my bible. You can subscribe to their website and get more current news than the FDA provides, or biased information from the drug companies.

And what about your doctor? Most of us trust our physicians to prescribe the right meds and think it unfathomable that we could be given a harmful drug. Yesterday I asked health expert Judy Norsigian of Our Bodies Ourselves to shed some light on the doctor dilemma with drugs.

She told me that many doctors don’t keep track of the latest findings and what happens with post-marketing surveillance. “Reports from the medical community usually become one of the key ways we find out about low level effects of any drugs, and not all the information from clinical trials, because there are not enough [people] involved in the trials to collect data,” Norsigian explained. ” And doctors are not always paying attention, so they aren’t even aware that there is a problem…”

All the more reason to do your own research, both online and by talking to your doctor and pharmacist about possible side effects. Another great source is the online Physicians’ Desk Reference. Just keep in mind that you can’t rely on the FDA (the “Foot Dragging Administration” as columnist Herb Denenberg calls it) to protect you.

Tags: Reglan, Reglan Side Effects, Tardive Dyskinesia

This was posted on Wednesday, February 3rd, 2010 at 1:20 pm and is filed under Drugs/Medical . Feel free to respond, or trackback. Read our comments policy.